Amiodarone‐induced pulmonary toxicity (AIPT), although rare, is a potentially life‐threatening adverse reaction 1. A 74-year-old man, a current smoker, presented with shortness of breath and a dry cough.
With long-term use, the prevalence of such toxicity varies between 5% and 15%.Symptoms can include progressive dyspnea, dry cough, malaise and pleuritic chest pain. We do not capture any email address. Amiodarone-induced pulmonary toxicity can present acutely (hours to days after surgery or angiography) or chronically (months to years after starting amiodarone treatment). This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Recent studies have reported that the incidence of AIPT ranges between 5 and 13% 2-5.
The mechanism of toxicity is unclear, but dose, interaction with other chemotherapeutic agents ... a dry cough, diffuse dry crackles and syncope. Recent studies have reported that the incidence of AIPT ranges between 5 and 13% [2–5].
Other potential causes of dyspnea were excluded (e.g. Dose and duration of treatment are not the only determinants of toxicity Copyright © 2020 BMJ Publishing Group Ltd 京ICP备15042040号-3 Amiodarone is an effective antiarrhythmic drug that was originally developed as an antianginal agent because of its vasodilator actions. Bilateral, ground-glass opacities (white arrows), high-attenuation infiltrates (black arrows), traction bronchiectases (white arrowheads) and honeycombing (black arrowheads) suggest amiodarone-induced pulmonary toxicity, in addition to emphysema (white asterisk).Amiodarone is associated with a wide range of adverse effects, including pulmonary toxicity. amiodarone pulmonary toxicity.5 Moreover, amiodarone and other cationic amphiphilic drugs are known to cause cornea verticillata indistinguishable from that of Fabry disease.6 Therefore, we suspected that amiodarone was the cause of her phospholipidosis. He had a history of ventricular tachyarrhythmia treated with amiodarone (200 mg/d for 6 years), a previous myocardial infarction and coronary artery bypass surgery.On examination, bilateral crackles could be heard on inspiration. Amiodarone is associated with a wide range of adverse effects, including pulmonary toxicity. Please note: your email address is provided to the journal, which may use this information for marketing purposes. The incidence of pulmonary toxicity from amiodarone is not precisely known; it is estimated to be 1 to 5 percent, depending on the dose of amiodarone . Amiodarone was discontinued due to suspicion of pulmonary toxicity and prednisone was started. Radiography of the patient’s chest showed diffuse interstitial and alveolar opacities, and echocardiography showed mild dysfunction of the left ventricle with an ejection fraction of 48%. Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis, and N -desethylamiodarone (DEA), an AM metabolite, may contribute to AM toxicity. Suspicion should be heightened in patients whose daily dose of amiodarone has been more than 400 mg for more than two months or in whom a low dose has been given for more than two years.Subscribe and get access to all BMJ articles, and much more.You can download a PDF version for your personal record.If you are unable to import citations, please contact We do not capture any email address.All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.Third Department of Cardiology, Silesian Center for Heart Disease, Medical University of Silesia, Zabrze, Poland.Third Department of Cardiology, Silesian Center for Heart Disease, Medical University of Silesia, Zabrze, Poland.To sign up for email alerts or to access your current email alerts, enter your email address below:Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect?Amiodarone: review of pulmonary effects and toxicityRapidly enlarging scalp nodules in a 20-month-old child Amiodarone-induced pulmonary toxicity (AIPT), although rare, is a potentially life-threatening adverse reaction [1].
Despite its clinical importance, there remain some unanswered questions regarding AIPT. High-resolution computed tomography showed signs consistent with amiodarone-induced interstitial pulmonary fibrosis (High-resolution computed tomography images of the chest of a 74-year-old man with dyspnea and cough. pulmonary embolism, infection, etc.).
Clubbing was absent.
Acetaminophen Side Effects Ampicillin, How Do Antidepressants Make You Feel Alesse, Atrovent Drug Interactions Amitriptyline, Toppik Colored Hair Thickener Black Alphagan, Balovaptan Clinical Trial Cordarone, Spanish Workbook For Beginners Viagra Plus, Why Does Azelastine Hcl Nasal Spray Cause Weight Gain Hydrea, Itraconazole For Cats Without Vet Prescription Minipress, Tylenol Suppository Dosage Roxithromycin, Can Amoxicillin Raise Your Blood Sugar? Myambutol, Things To Avoid When You Have Glaucoma Prilosec, Donepezil Nursing Implications Volume Pills, Piracetam Comanda Online Cialis Professional, Can You Dissolve Mirtazapine In Water Red Viagra, Prescription Drugs Seized By Customs Clonidine, Lutein Macular Degeneration Prevention Silagra, Tea Theobromine And Theophylline Content Tadacip, Can Warfarin Cause Anemia Prandin, Life Pharmacy Code Uae Tadacip, Elementary Spanish Vocabulary Prednisolone, Mebendazole Dose For Adults Super Force Jelly, What Medications Can Cause Atrial Fibrillation Brand Premarin, United Pharmacies Shut Down Himplasia, Flixonase Nasal Spray Composition Actos, Can You Take Prochlorperazine With Omeprazole Rumalaya, Nurx Address Prinivil, Urinary Incontinence Treatment Natural Kamagra Flavored, Proair Respiclick Dose Buspar, Best Multivitamin For Hypothyroidism Minocycline, Magnesium Itching Motrin, Does Amoxicillin Affect Nexplanon Voltaren, Disadvantages Of Deworming Actos, Soy Isoflavones BFP Stories Mobic, Hmm Meaning Hug Me More Paroxetine, Getting Pregnant On Fluoxetine Pepcid, How To Avoid Weight Gain On Glipizide Lasuna, Switching From Nebivolol To Metoprolol Lopid, New Treatments For Dry Macular Degeneration Speman, Express Scripts Home Delivery Tulasi, Metoprolol Quizlet Metformin, Daily Spanish Vocabulary Entocort, Dexamethasone Vs Albuterol Benzac, Buy Periactin Online, Zofran Pediatric Dose Gastroenteritis Zofran, Mannose Disaccharide Protonix, Apo-fluticasone Hyzaar, How Much Does Aromatase Inhibitor Reduce Risk Of Recurrence Allegra, Propiedades Físicas Ejemplos Red Viagra, Pharmachoice Pharmacy Glucotrol Xl, Clindamycin For Cellulitis Super P-force, Bipolar And Alcohol Stories Sublingual Cialis, Parkinson's Disease And Therapy Lovegra, Losartan 145 Recall Effexor Xr, Nifedipine Ointment Cipro, Does Medicaid Cover Vyvanse Levitra Soft, Aminophylline Toxic Dose Kamagra Gold, How To Get Finasteride Prescription Prograf, Mielle Organics Reviews Minocycline, How Much Rimadyl Will Kill A Dog Betnovate, Kamagra Oral Jelly 100mg Price, Generic Olmesartan Reviews Estrace, Mail Order Premarin Prednisolone, Ketoprofen Cream Karela, Itraconazole With Milk Paroxetine, How Much Does Aromatase Inhibitor Reduce Risk Of Recurrence Allegra, Pyridostigmine Bromide Brand Name Tadapox, Azithromycin Action Sildalis, Theophylline Action Herbal Extra Power, Menopause Max Reviews Skelaxin, Ben And Jerry's Halloween Flavors 2019 Cystone, How Long Do Letrozole Side Effects Last Coversyl, Altreno Vs Tretinoin Colchicine,
