Acetaminophen Suppositories - 113 DPL. Dans la mesure du possible, établissez la dose en fonction du poids de votre enfant; sinon, en fonction de son âge. Dashed lines represent serum concentrations in patients resulting from subsequent 20-mg/kg doses at 6-h intervals. Nitrous oxide with halothane or isoflurane was used to maintain anesthesia.
But, taking too much of this medicine can be harmful. J Paediatr Child Health 1998; 34: 425–31Roller L: The formulation, dissolution and bioavailability of paracetamol suppositories. Concentrations more than 300 μg/ml 4 h after oral ingestion are associated with severe liver damage, whereas toxicity is generally not seen with concentrations less than 120 μg/ml. Combinations of the four commercially available doses (80, 120, 325, and 650 mg) were used to deliver a dose for each patient as close as possible to the desired dose. It is important to note that maximum daily doses and labeling instructions differ between Canada and the United States. We selected a target range of 10–20 μg/ml because that serum concentration is reported to produce antipyresis. Acetaminophen suppository dosing for children 3 to 36 months old typically starts at 80 mg. Suppositories were not cut, because acetaminophen may not be distributed evenly throughout the suppository.Children aged 2–12 yr undergoing elective orthopedic surgery were eligible if they were to be hospitalized after surgery, weighed more than 12 kg, were classified as American Society of Anesthesiologists physical status 1–3, and had a preoperative hematocrit more than 30%. To use suppository, take off foil wrapper. 1. Although serum concentration exceeded 20 μg/ml in five patients, the peak serum concentration observed at any time during the 24-h sampling period was less than 40 μg/ml, and only two patients had peak serum concentrations more than 30 μg/ml.
Quality of fit of the measured serum concentrations to those predicted from our published pharmacokinetic model, which assumes dissolution of suppositories is a zero-order process and absorption is a first-order process. In this suppository formulation, acetaminophen is suspended in a hydrogenated vegetable oil base.
Lin Differences exist between oral and rectal bioavailability, although data are limited. J Pediatr 1998; 132: 22–7Prescott LF: Paracetamol (Acetaminophen): A Critical Bibliographic Review. Anesthesiology 1997; 87: 244–52Rusy LM, Houck CS, Sullivan LJ, Ohlms LA, Jones DT, McGill TJ, Berde CB: A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: Analgesia and bleeding. Bristol, Taylor & Francis, 1996, pp 443–6Anderson BJ, Holford NHG: Rectal acetaminophen pharmacokinetics (letter). Search for other works by this author on: The coefficients of variation were 7.5% and 4.3%, respectively, during the study.To assess whether our dosing regimen achieved the target concentration of 10–20 μg/ml, we determined the fraction of time that each individual maintained a serum acetaminophen concentration between 10 and 20 μg/ml from initial administration until 6 h after the final dose (or until the final sample was obtained). New Guidelines Urge OTC Painkillers, Not Opioids For oral and rectal dosage forms (capsules, granules, powders, solution, suppositories, suspension, or tablets): Adults and teenagers—650 to 1000 milligrams (mg) every 4 to 6 hours as needed. Search for other works by this author on: ml = millilitre c. à thé = cuillère à thé REMARQUE: La dose unitaire peut être répétée toutes les 4 à 6 heures, au besoin. This dosing regimen was determined using previous pharmacokinetic parameter estimates.
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