The major metabolite-desloratadine (DL)- is pharmacologically active and responsible for a large part of the clinical effect. Loratadine is dosed in dogs at 0.1 mg per pound to 0.55 mg per pound of body weight (0.25 to 1.1 mg/kg) once daily or divided twice daily. Child: 2-12 years <30 kg: 5 mg once daily; >30 kg: 10 mg once daily. Continue typing to refine. Dose may be increased to 25 to 50 mg every two to three hours. When suggestions are available use up and down arrows to review and ENTER to select.



2002 Pharmacology, adverse reactions, warnings and side effects. this question is to dr Kanodia. 2010

Body weight more than 30kg: 10ml (10mg) of the syrup once daily; Body weight 30kg or less: 5ml (5mg) of the syrup once daily. Oral Allergic conditions. If you log out, you will be required to enter your username and password the next time you visit. 2-6 years: 5 mg PO qDay >6 years: 10 mg PO qDay; not to exceed 10 mg qDay. Drugs However, prolonged parturition and reduced viability of offspring were observed in rats at plasma levels (AUC) 10 times higher than those achieved with clinical doses.This medicinal product does not require any special storage conditions. This information is intended for use by health professionalsBoots Hayfever Relief All Day 5mg/5ml Oral SolutionEach 1 ml of syrup also contains the following excipients:Loratadine 5mg/5ml Syrup is indicated for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticarial in adults and children over the age of 2 years.Body weight more than 30kg: 10ml (10mg) of the syrup once daily;Body weight 30kg or less: 5ml (5mg) of the syrup once daily.Efficacy and safety of Loratadine 5mg/5ml Syrup in children under 2 years of age has not been established.Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine.

The mean elimination half-lives of loratadine and its metabolite were not significantly …

Medical monitoring of the patient is to be continued after emergency treatment.Loratadine, the active ingredient in Loratadine 5mg/5ml Syrup, is a tricyclic antihistamine with selective, peripheral HLoratadine has no clinically significant sedative or anticholinergic properties in the majority of the population and when used at the recommended dosage. 2001 Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Efficacy and safety of Loratadine 5mg/5ml Syrup in children under 2 years of age has not been established. Children 4 years of age and older—1 to 1.5 mg per kg (0.45 to 0.68 mg per pound) of body weight injected into a muscle every six hours. Loratadine and DL achieve maximum plasma concentrations (TIncrease in plasma concentrations of loratadine has been reported after concomitant use with ketoconazole, erythromycin, and cimetidine in controlled trials, but without clinically significant changes (including electrocardiographic).Loratadine is highly bound (97% to 99%) and its active metabolite moderately bound (73% to 76%) to plasma proteins.In healthy subjects, plasma distribution half-lives of loratadine and its active metabolite are approximately 1 and 2 hours, respectively. /viewarticle/936363 In patients with chronic renal impairment, both the AUC and peak plasma levels (Cmax) increased for loratadine and its metabolite as compared to the AUCs and peak plasma levels (Cmax) of patients with normal renal function. However, they also found that there was no increased benefit with twice the dosage over the normal dose. Administration of activated charcoal as a slurry with water may be attempted. Approximately 27% of the dose is eliminated in the urine during the first 24 hours. 10 mg PO qDay or 5 mg twice daily; not to exceed 10 mg qDayRenal impairment (GFR <30 mL/min): 10 mg PO every other dayAutonomic nervous system: Altered lacrimation, altered salivation, flushing, hypoesthesia, impotence, increased sweating, thirstCardiovascular: HTN, hypotension, palpitations, supraventricular tachyarrhythmias, syncope, tachycardiaCNS: Blepharospasm, dizziness, dysphonia, hypertonia, migraine, paresthesia, tremor, vertigoGI: Altered taste, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastritis, hiccup, increased appetite, loose stools, nausea, vomitingPsychiatric: Agitation, amnesia, anxiety, confusion, decreased libido, depression, impaired concentration, insomnia, irritability, paroniriaReproductive: Breast pain, dysmenorrhea, menorrhagia, vaginitisRespiratory: Bronchitis, bronchospasm, coughing, dyspnea, hemoptysis, laryngitis, nasal dryness, sinusitis, sneezingSkin: Dermatitis, dry hair, dry skin, photosensitivity reaction, pruritus, purpura, urticariaUrinary: Altered micturition, urinary discoloration, urinary incontinence, urinary retentionElderly patients are at increased risk for comorbidities related to anticholinergic effects; may be potentially inappropriate in this population (Beers criteria)Effects of ethanol and other sedative drugs may be potentiated when used concurrentlyBenzyl alcohol, which is associated with the fatal toxicity, gasping syndrome in neonates; use cautionLactation: Excreted in breast milk; avoid (AAP Committee states compatible with nursing)A: Generally acceptable.

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