FDA drug safety communication: abnormal heart rhythms may be associated with use of Zofran (ondansetron).
Available for Android and iOS devices. Diarrhea was a consistent adverse effect, but due to varying measurements, the NNH could not be calculatedDiarrhea was a consistent adverse effect, but due to varying measurements, the NNH could not be calculatedThe mainstay of gastroenteritis treatment in the emergency department involves rehydration, preferably through oral means. Sep 8, 2020 The following information is NOT intended to endorse any particular medication.
However, this is unlikely, given the similar baseline characteristics of the two groups and the fact that Ramsook et al.We used an unvalidated scale for dehydration because of the lack of an externally validated scale and the conclusion of a recent meta-analysis that individual signs of dehydration are imprecise and inaccurate.We chose not to use the WHO classification of dehydration (no dehydration, some dehydration, and severe dehydration),The oral-rehydration period in the emergency department was limited to one hour to mimic routine clinical practice, in which prolonged periods of observation are impractical. A recent retrospective multicenter cohort study from 2002-2011 of the use of ondansetron in pediatric emergency room settings found that ondansetron use increased substantially …
Corresponding doses of ZOFRAN tablets, ZOFRAN ODT ® orally disintegrating tablets and ZOFRAN oral solution may be used interchangeably. Since the decision to administer intravenous fluids was made by the supervising physician, who was unaware of patients' treatment assignments, we believe this difference represents a true effect of treatment.Ondansetron did not reduce the hospitalization rate (4 percent overall). Corresponding doses of ZOFRAN tablets, ZOFRAN ODT ® orally disintegrating tablets and ZOFRAN oral solution may be used interchangeably. Urticaria developed in one child in the placebo group. As compared with children who received placebo, children who received ondansetron had fewer episodes of vomiting, greater oral intake of fluids, and a shorter stay in the emergency department.To prevent vomiting in 1 child, 5 children had to receive ondansetron (95 percent confidence interval, 3.2 to 10.6); to prevent 1 child from having to be treated by intravenous rehydration, 6 had to receive ondansetron (95 percent confidence interval, 3.6 to 17.0).
We conducted a double-blind trial to determine whether a single oral dose of ondansetron, an antiemetic, would improve outcomes in children with gastroenteritis.We enrolled 215 children 6 months through 10 years of age who were treated in a pediatric emergency department for gastroenteritis and dehydration. Nausea/Vomiting: 4-8mg q4h, max 24mg a day; Pediatric Dosing.
Each of these children was given a second dose, which was tolerated. Dose: 0.15 mg/kg/dose IV q4h x3 doses; Start: 30min before chemo; Max: 16 mg/dose [PO route, moderately-emetogenic chemo, 4-11 yo] Dose: 4 mg PO q4h x3 doses, then 4 mg PO q8h until 1-2 days after chemo complete; Start: 30min before chemo; Info: do not cut/chew ODT form Prescription patterns and use of antiemetic medications such as promethazine, metoclopramide, dimenhydrinate and domperidone vary considerably [8][9]. Faecal samples may be collected for bacterial culture if the child has significant associated abdominal pain or blood in the faeces, as a bacterial cause of gastroenteritis is more likely. In this case, there are many research studies that show that Zofran can be helpful for treating and preventing vomiting associated with acute gastroenteritis. Since the tablet dissolves in seconds and does not require the coadministration of liquids, aspiration was not considered to be a risk.
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