He is also an instructor in family medicine at Jefferson Medical College of Thomas Jefferson University, Philadelphia.
Access This ArticlePAUL W. AMENT, PHARM.D., is assistant director of pharmacy and a faculty member in the family medicine residency program at Latrobe (Pa.) Area Hospital. Many of these side effects can be managed, and some may go away on their own over time.Is it time to see a doctor about your toenails? Mason BJ, Preskorn SH, All SSRIs except paroxetine (Paxil) have pharmacologically active metabolites.The most common interactions with SSRIs result from an inhibitory effect of the SSRI on the cytochrome P450 2D6 pathway, although variability in this inhibition exists.
Monitor carbamazepine levels.Decrease lithium dosage by 50% and monitor lithium levels.Avoid if possible. One study of patients at high risk for thromboembolic events (i.e., patients with mechanical heart valves or the combination of tissue valves and atrial fibrillation) demonstrated that the increased risk of bleeding with combined warfarin and aspirin therapy was outweighed by the benefit in decreased thromboembolic events.Coadministration of nonsteroidal anti-inflammatory drugs (NSAIDs) and warfarin increases the risk of bleeding. Consult your doctor before taking Dilantin if pregnant or breastfeeding.
Serious adverse effects of combining fluoxetine and tricyclic antidepressants [Letter]. Monitor phenobarbital levels.Clinical significance has not been established. Use the dosing cup supplied with itraconazole solution to measure doses accurately.Grapefruit juice may reduce the effectiveness of itraconazole.Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. Itraconazole capsules are also used to treat fungal infections of the fingernails.
Store this medication at room temperature and keep it out of the reach of children. Acetaminophen and other risk factors for excessive warfarin anticoagulation. These problems are most likely to occur with formulations containing a low dosage of estrogen (less than 35 μg of ethinyl estradiol).The interaction between oral contraceptives and other antibiotics is controversial in that no definitive studies have demonstrated contraceptive failure from such combinations.
Generic Name: itraconazole (IT ra KON a zole) Brand Names: Sporanox, Sporanox PulsePak What is itraconazole? As a result, serum lithium levels increase secondary to enhanced reabsorption.If coadministration is necessary, the dosage of lithium should be reduced by 50 percent when a diuretic or an NSAID is added. Sumatriptan contraindications and the serotonin syndrome. If combination therapy is necessary, recommend use of alternative contraceptive method during cycle.Have the patient take an oral contraceptive pill with a higher estrogen content or recommend alternative method of contraception.Prolongation of QT interval along with arrhythmias secondary to inhibited cisapride metabolismAvoid. Seek emergency medical attention or call the Poison Help line at The Sporanox capsule should be taken with food. 53rd ed. Almost all antibiotics can potentiate the effects of warfarin by inhibiting intestinal flora that produce vitamin K. Inhibition of the hepatic metabolism of warfarin is another possible mechanism for increased bleeding.Clinical trials evaluating warfarin-antibiotic combinations have had mixed outcomes.Unless the prothrombin International Normalized Ratio (INR) can be monitored every other day, ciprofloxacin, macrolide antibiotics, metronidazole and trimethoprim-sulfamethoxazole generally should not be prescribed to patients who are taking warfarin. [Letter] Joffe RT, Krishnarao I.
Kaplan-Machlis B, If combination therapy is necessary, monitor the patient for signs and symptoms of serotonin syndrome.Use lowest possible acetaminophen dosage and monitor INR.Limit aspirin dosage to 100 mg per dayand monitor INR.Avoid concomitant use if possible; if coadministration is necessary, use a cyclooxygenase-2 inhibitor and monitor INR.Clinical significance has not been established. A WARNING ABOUT MILK THISTLE AND DRUGS The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances.
Continue to take itraconazole until your doctor tells you to stop even if you feel well. Reaven P,
Sporanox Capsules: Itraconazole belongs to the family of medications called antifungals.
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