Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Blood and lymphatic system disorders: increased bleeding tendency, thrombocytopenia.Immune system disorders: hypersensitivity reactions including anaphylaxis, hepatic eosinophilic infiltration.Psychiatric disorders: including, but not limited to, agitation, aggressive behavior or hostility, anxiousness, depression, disorientation, disturbance in attention, dream abnormalities, dysphemia (stuttering), hallucinations, insomnia, irritability, memory impairment, obsessive-compulsive symptoms, restlessness, somnambulism, suicidal thinking and behavior (including suicide), tic, and tremor Nervous system disorders: drowsiness, paraesthesia/hypoesthesia, seizures.Respiratory, thoracic and mediastinal disorders: epistaxis, pulmonary eosinophilia.Gastrointestinal disorders: diarrhea, dyspepsia, nausea, pancreatitis, vomiting.Hepatobiliary disorders: Cases of cholestatic hepatitis, hepatocellular liver-injury, and mixed-pattern liver injury have been reported in patients treated with Singulair. The study is created by eHealthMe based on reports of 3,229 people who take Singulair and Tylenol from the FDA, and is updated regularly.
Orally administered montelukast distributes into the brain in rats.Montelukast is extensively metabolized. anti-histamines are most commonly used for allergies such as benadryl, but is often found in OTC sleep aids, and some older anti-histamines have anxiolytic effects, and many other uses. The pharmacokinetics of montelukast are similar whether dosed in the morning or evening. The median age in this trial was 35.0 years (range 15 to 81); 65.4% were females and 34.6% were males. In the Multinational study, significantly fewer patients (14.8% of patients) on Singulair were prescribed oral corticosteroids for asthma rescue compared with patients on placebo (25.7%, p<0.001). Call your doctor for medical advice about side effects. SINGULAIR 4-mg oral granules can be administered either directly in the mouth, dissolved in 1 teaspoonful (5 mL) of cold or room temperature baby formula or breast milk, or mixed with a spoonful of cold or room temperature soft foods; based on stability studies, only applesauce, carrots, rice, or ice cream should be used. Data available on the effects of the drug on infants, either directly Safety and efficacy of Singulair have been established in adequate and well-controlled studies in pediatric patients with asthma 6 to 14 years of age. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Try searching for what you seek or The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. The two studies enrolled a total of 3357 patients, of whom 1632 received Singulair 10-mg tablets. Most of these occurred in combination with other confounding factors, such as use of other medications, or when Singulair was administered to patients who had underlying potential for liver disease such as alcohol use or other forms of hepatitis.Skin and subcutaneous tissue disorders: angioedema, bruising, erythema multiforme, erythema nodosum, pruritus, Stevens-Johnson syndrome/toxic epidermal necrolysis, urticaria.Musculoskeletal and connective tissue disorders: arthralgia, myalgia including muscle cramps.General disorders and administration site conditions: edema.Patients with asthma on therapy with Singulair may present with systemic eosinophilia, sometimes presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition which is often treated with systemic corticosteroid therapy. You have an infection that requires immediate treatment. The pharmacokinetic profile and the oral bioavailability of a single 10-mg oral dose of montelukast are similar in elderly and younger adults. In a 56-week, double-blind study evaluating growth rate in pediatric patients 6 to 8 years of age receiving Singulair, the following events not previously observed with the use of Singulair in this age group occurred with a frequency ≥2% and more frequently than in pediatric patients who received placebo: headache, rhinitis (infective), varicella, gastroenteritis, atopic dermatitis, acute bronchitis, tooth infection, skin infection, and myopia.Singulair has been evaluated for safety in 573 pediatric patients 2 to 5 years of age in single- and multiple-dose studies.
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