Beta-blockers may increase the hypoglycaemic effect of antidiabetic medicinal products.

However, at therapeutic doses of timolol in eye drops it is not likely that sufficient amounts would be present in breast milk to produce clinical symptoms of beta-blockade in the infant. Excipients with known effect: benzalkonium chloride 0.150 mg/ml, macrogol glycerol hydroxy stearate 40 5 mg/ml (see section 4.4. One route yields an ethanolamine side chain on the thiadiazole ring and the other gives an ethanolic side chain on the morpholine nitrogen and a second similar side chain with a carbonyl group adjacent to the nitrogen. Hence, despite the very small amounts of travoprost used by patients in eye drops, a risk to the environment cannot be excluded.Before opening, keep bottle in overwrap pouch in order to protect from moisture.After first opening, this medicinal product does not require any special storage conditions. Patients with severe peripheral circulatory disturbance/disorders (i.e.

When measurable (≥ 0.01 ng/ml, the assay limit of quantitation), concentrations ranged from 0.01 to 0.03 ng/ml. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. O 02. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme (www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store).A topical overdose with Travoprost/Timolol Aspire is not likely to occur or to be associated with toxicity. Existing data suggest that evening dosing might have some advantages as regards mean IOP reduction. of adrenaline.

Topical ocular administration of travoprost to monkeys at concentrations of up to 0.012% to the right eye, twice daily for one year resulted in no systemic toxicity. Travoprost is in a class of medications called prostaglandin analogs. This color change may be permanent, but the long-term effects are uncertain.

Unilateral treatment can result in permanent heterochromia.

In a twelve-month, controlled clinical study in patients with open-angle glaucoma or ocular hypertension and baseline mean IOP of 25 to 27 mmHg, the mean IOP-lowering effect of travoprost/timolol 40 micrograms/ml + 5 mg/ml eye drops, solution dosed once daily in the morning was 8 to 10 mmHg.

Along with its needed effects, travoprost ophthalmic may cause some unwanted effects.

No dosage adjustment is necessary in these patients. Prostaglandins and prostaglandin analogues are biologically active materials that may be absorbed through the skin.

If Travoprost/Timolol Aspire is administered until delivery, the neonate should be carefully monitored during the first days of life. Benzalkonium chloride has been reported to cause eye irritation, symptoms of dry eyes and may affect the tear film and corneal surface. Each bottle contains 2.5 ml solution.
In patients with known predisposing risk factors for iritis/uveitis, Travoprost should be used with caution. Cerner Multum, Inc. "UK Summary of Product Characteristics." In pregnant rats, systemic administration of travoprost at doses more than 200 times the clinical dose during the period of organogenesis resulted in an increased incidence of malformations. Beta-blocking ophthalmological preparations may block systemic beta-agonist effects, e.g. Mean IOP reduction at Week 12 in the 2 months to < 3 years of age group was 1.8 mmHg in the travoprost group and 7.3 mmHg in the timolol group. Travoprost free acid, a prostaglandin analog is a selective FP prostanoid receptor agonist which is believed to reduce intraocular pressure by increasing uveoscleral outflow.

When substituting another ophthalmic antiglaucoma medicinal product with Travoprost, the other medicinal product should be discontinued and Travoprost should be started the following day.Travoprost has been studied in patients with mild to severe hepatic impairment and in patients with mild to severe renal impairment (creatinine clearance as low as 14 ml/min). Patients with hepatic or renal impairment are unlikely to require dose adjustment with Travoprost/Timolol Aspire (see section 5.2).The safety and efficacy of travoprost/timolol 40 micrograms/ml + 5 mg/ml eye drops, solution in children and adolescents below the age of 18 years have not been established.

However, data in the age group 2 months to < 3 years (9 patients) is limited (see section 5.1).The safety and efficacy of Travoprost in children below the age of 2 months have not been established.

Optimal effect is obtained if the dose is administered in the evening.

Tonography and fluorophotometry studies in man suggest that its predominant action is related to reduced aqueous humour formation and a slight increase in outflow facility.Travoprost significantly increased optic nerve head blood flow in rabbits following 7 days of topical ocular administration (1.4 micrograms once daily). Timolol does not dialyse readily.Pharmacotherapeutic group: Ophthalmologicals; Antiglaucoma preparations and miotics, ATC code: S01ED51.

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