Weight Gain following Initiation of Antiretroviral Therapy This retrospective observational cohort study analyzed data from 1,152 persons following their initiation of antiretroviral therapy. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Confidence intervals give similar information to p-values but are easier to interpret. Although there is some evidence that dolutegravir might interact with a hormonal signalling system that influences calorie intake and energy use, more research is needed to determine if this explains the association between the drug and weight gain.However, the strongest association detected in the study was between low CD4 count and weight gain, suggesting that weight gain represents a 'return to health' phenomenon in this group of people. He or she may also look for other causes of weight gain, such as certain types of medical conditions. "The trend towards greater weight gain with newer regimens may be a consequence of better gastrointestinal tolerability and less nausea. This included 351 persons receiving an integrase strand transfer inhibitor (135 on dolutegravir, 153 elvitegravir, and 63 raltegravir). Registered charity, number: 1011220NAM exists to support the fight against HIV & AIDS with independent, accurate accessible and comprehensive information. More weight was gained in the most recent studies and more weight was gained by people taking the investigational regimen in every study.Low CD4 count and injecting drug use were the factors associated with greatest weight gain over 96 weeks of follow-up, followed by black race and baseline viral load above 100,000 copies/ml.People with CD4 counts below 200 gained more weight than people with higher CD4 counts (+2.97kg, 95% CI 2.81-3.13, p<0.001) and gains in weight closely tracked gains in CD4 count over time. A CD4 count below 200 was also the strongest risk factor for a weight gain of at least 10% of baseline weight (odds ratio 4.36, 95% CI 3.6-5.27, p<0.001).People who injected drugs gained more weight than those who did not (+1.41kg, 95% CI 0.97-1.85, p<0.001).People with symptomatic HIV or AIDS at baseline gained 0.51kg (95% CI 0.36-0.65, p<0.001) more than people who were asymptomatic.Race was associated with greater weight gain than gender. Integrase strand transfer inhibitors (INSTIs) block integrase, which is an HIV enzyme that the virus uses to insert its genetic material into a cell that it has infected.
July 27, 2018. If the weight gain continues, he or she may also recommend other lifestyle changes or possibly switch you to another Race was associated with greater weight gain than gender. Site users seeking medical advice about their specific situation should consult with their own physician. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. But it’s an unfortunate side effect of many common medications.
We aim to create and disseminate information resources rooted in the experience of those most affected, enabling individuals and communities to take action and control in responding to HIV & AIDS.A high success rate was seen halfway into a 48-week study in which people with HIV started treatment within two weeks of diagnosis. o Fruits, vegetables, grains, and fat-free or low-fat milk and milk productso Lean meats, poultry, fish, beans, eggs, and nuts.If you continue to gain weight, see your healthcare provider.
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