The recommended dose of XELODA is 1250 mg/m 2 administered orally twice daily (morning and evening; equivalent to 2500 mg/m 2 total daily dose) for 2 weeks followed by a 1-week rest period given as 3-week cycles (see Table 1). The median duration of grade 3 to 4 diarrhea was 5 days. Two hundred and fifty-five (255) patients were randomized to receive XELODA 1250 mg/mXELODA in combination with docetaxel resulted in statistically significant improvement in time to disease progression, overall survival and objective response rate compared to monotherapy with docetaxel as shown in The antitumor activity of XELODA as a monotherapy was evaluated in an open-label single-arm trial conducted in 24 centers in the US and Canada. You might have two different strengths of tablets to make up the correct dose. If you are a consumer or patient please visit The major metabolite excreted in urine is FBAL which represents 57% of the administered dose.
54868-5260-2, KEEP TIGHTLY CLOSED.Care should be exercised in the handling of XELODA. You might have two different strengths of tablets to make up the correct dose. Many tissues throughout the body express thymidine phosphorylase. Contact your advice line as soon as possible if:Early treatment can help manage side effects better. 54868-5260-5,
My beloved Xeloda.
5-year Disease-free Survival Rates (%)
Following grade 3 hand-and-foot syndrome, subsequent doses of XELODA should be decreased In 875 patients with either metastatic breast or colorectal cancer who received at least one dose of XELODA 1250 mg/mIn the 596 patients treated with XELODA as first-line therapy for metastatic colorectal cancer, the incidence of grade 3 or 4 hyperbilirubinemia was similar to the overall clinical trial safety database of XELODA monotherapy. People with a DVT are at risk of developing a pulmonary embolism. Tell your specialist team if you experience any of these symptoms.Diarrhoea is common during treatment, and sometimes this can be severe.
This depends on your individual treatment plan.
But these services are not available in every hospital, so you would need to ask your doctor about this. Your appointment will usually be with a nurse.
The enzyme, thymidine phosphorylase (dThdPase), then hydrolyzes 5'-DFUR to the active drug 5-FU. The recommended dose of XELODA was determined in an open-label, randomized clinical study, exploring the efficacy and safety of continuous therapy with capecitabine (1331 mg/m 2 /day in two divided doses, n=39), intermittent therapy with capecitabine (2510 mg/m 2 /day in two divided doses, n=34), and intermittent therapy with capecitabine in combination with oral leucovorin (LV) …
In this trial, 1987 patients were randomized either to treatment with XELODA 1250 mg/mThe baseline demographics for XELODA and 5-FU/LV patients are shown in All patients with normal renal function or mild renal impairment began treatment at the full starting dose of 1250 mg/mThe median follow-up at the time of the analysis was 83 months (6.9 years). Having capecitabine increases the risk of blood clots such as deep vein thrombosis (DVT). You take it twice a day, morning and evening.
Registered Office: Fifth Floor, Ibex House, 42-47 Minories, London EC3N 1DY. Using a moisturising cream can also help.If you experience skin reactions, mention this to your specialist when you see them next so that the symptoms can be managed.Some people have nausea (feeling sick) during their treatment.
treatment can either be given every two or three weeks depending on what your doctor feels is best for you. Your height and weight will help us to calculate how many If this isn't possible, wash your hands well after changing their nappy.For further information about this treatment go to the electronic Medicines Compendium (eMC) website.You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.iWantGreatCare lets patients leave feedback on their experience of taking a particular drug. You might have one or more of them. Some human carcinomas express this enzyme in higher concentrations than surrounding normal tissues. Find out more about You can lose your appetite while taking capecitabine.
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