2018 Mar 1;228:229-237. doi: 10.1016/j.jad.2017.12.021. Mirtazapine, sold under the brand name Remeron among others, is an antidepressant primarily used to treat depression.
Site users seeking medical advice about their specific situation should consult with their own physician. None of the 26 infants exposed to mirtazapine in the first trimester were born with a major malformation. In order for us to best serve you and provide you with the best information, can you please tell us if you currently have health insurance? Mirtazapine also caused low birth weights and decreased the survival rates of newborn rats.
This eMedTV segment explains that the FDA has classified the drug as a pregnancy Category C medicine based on the results of animal studies. While we have adequate data to support the use of SSRI antidepressants during pregnancy, there is less data regarding other classes of antidepressants. Her postpartum dose was 15 mg daily or 224 mcg/kg daily. Often it is used in depression complicated by anxiety or trouble sleeping. Limited data of the use of mirtazapine in pregnant women do not indicate an increased risk for congenital malformations. Alprazolam (Xanax) D. Unknown, of concern.
A systematic literature search and review to inform clinical practice J Affect Disord. This case series included 56 cases exposed to mirtazapine during pregnancy and lactation. Copyright 2018 MGH Center for Women's Mental Health | All Rights Reserved | Site Developed by Keep up with the latest news in women’s mental health and our research.
For Adult. This suggests (although does not prove) that the small amounts of mirtazapine delivered to the baby in the breast milk may reduce the risk of any sort of withdrawal phenomena.Smit M, Wennink HJ, Heres MM, Dolman KK, Honig A. There are several situations where it may not be safe to take mirtazapine, and pregnancy is one of them.
Studies in animals have not shown any teratogenic effects of clinical relevance, however developmental toxicity has been observed (see section 5.3).
Whitehouse Station, NJ: Merck & Co., Inc.;2012 October.Briggs GG, Freeman RK, Yaffe SJ.
Remeron [package insert]. This site does not dispense medical advice or advice of any kind. Limited data of the use of mirtazapine in pregnant women do not indicate an increased risk for congenital malformations. [3] A woman took mirtazapine 15 to 30 mg daily throughout the second and third trimesters of pregnancy and during breastfeeding. Drugs in Pregnancy and Lactation. This incidence (25.9%) is similar to the incidence of PNAS after exposure to other antidepressants. In order for us to create your customized HealthSavvy programs, we need a little more information about the health topic(s) that you are interested in. Studies in animals have not shown any teratogenic effects of clinical relevance, however developmental toxicity has been observed (see section 5.3).
The number of exposed to mirtazapine in this study is too small to rule out the possibility that mirtazapine increases the risk of malformations. That means two things: Research in animals has shown adverse effects to the fetus when the mother takes the drug.
For pregnant women: Mirtazapine is a category C pregnancy drug. A new case series documents the outcomes of infants exposed to mirtazapine (Remeron).This case series included 56 cases exposed to mirtazapine during pregnancy and lactation.None of the 26 infants exposed to mirtazapine in the first trimester were born with a major malformation.
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