Serial liver function studies should be performed in these patients.False-positive Benedict's tests, due to an unknown reducing substance, have been noted. Subjects ranged in age from 18 to 48 years (mean age = 23.5 ± 5.7 years). Using the combined data, the results indicate that the pharmacokinetics of metaxalone are significantly more affected by age under fasted conditions than under fed conditions, with bioavailability under fasted conditions increasing with age. The empirical formula is CMetaxalone is a white to almost white, odorless crystalline powder freely soluble in chloroform, soluble in methanol and in 96% ethanol, but practically insoluble in ether or water.Each tablet contains 800 mg metaxalone and the following inactive ingredients: alginic acid, ammonium calcium alginate, B-Rose Liquid, corn starch, and magnesium stearate.The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system (CNS) depression.

Safe use of metaxalone has not been established with regard to possible adverse effects upon fetal development.

kaismama 9 Feb 2014. The results were analyzed separately, as well as in combination with the results from three other studies.

Doubling the dose of Skelaxin from 400 mg to 800 mg results in a roughly proportional increase in metaxalone exposure as indicated by peak plasma concentrations (CThe single-dose pharmacokinetic parameters of metaxalone in two groups of healthy volunteers are shown in Table 1.A randomized, two-way, crossover study was conducted in 42 healthy volunteers (31 males, 11 females) administered one 400 mg Skelaxin tablet under fasted conditions and following a standard high-fat breakfast.

Follow patients closely for signs and symptoms of respiratory depression and sedation (see Skelaxin should be administered with great care to patients with pre-existing liver damage.

I fail to understand why they don't just say that when they write the script, but this has been a question put to pharmacists for at least the past century. Subjects ranged in age from 18 to 48 years (mean age = 23.5 ± 5.7 years).
The results were analyzed separately, as well as in combination with the results from three other studies. Subjects ranged in age from 18 to 48 years (mean age = 23.5 ± 5.7 years).

Chemically, metaxalone is 5-[(3,5- dimethylphenoxy) methyl]-2-oxazolidinone. . SKELAXIN ® (metaxalone) is available as an 800 mg oval, scored pink tablet.. Instruct patients to inform their healthcare providers if they are taking, or plan to take, serotonergic medications (see The sedative effects of Skelaxin and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive. Instruct patients to inform their healthcare providers if they are taking, or plan to take, serotonergic medications (see The sedative effects of Skelaxin and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive. Doubling the dose of SKELAXIN from 400 mg to 800 mg results in a roughly proportional increase in metaxalone exposure as indicated by peak plasma concentrations (CThe single-dose pharmacokinetic parameters of metaxalone in two groups of healthy volunteers are shown in Table 1.A randomized, two-way, crossover study was conducted in 42 healthy volunteers (31 males, 11 females) administered one 400 mg SKELAXIN tablet under fasted conditions and following a standard high-fat breakfast. Don’t understand why some people are cocky giving response.This may sound lame to some but in re to prescription mine reads take one capsule 3 times a day, so if I took my first pill following dental surgery at 2:30pm then when would I take the other two? Consultation with a regional poison control center is recommended.The recommended dose for adults and children over 12 years of age is one 800 mg tablet three to four times a day.Skelaxin (metaxalone) is available as an 800 mg oval, scored pink tablet inscribed with 8667 on the scored side and "S" on the other.
Warn patients of the symptoms of serotonin syndrome and to seek medical attention right away if symptoms develop. Metaxalone does not significantly induce major CYP enzymes such as CYP1A2, CYP2B6, and CYP3A4 The effects of age on the pharmacokinetics of metaxalone were determined following single administration of two 400 mg tablets (800 mg) under fasted and fed conditions. Specifically, CYP1A2, CYP2D6, CYP2E1, and CYP3A4 and, to a lesser extent, CYP2C8, CYP2C9, and CYP2C19 appear to metabolize metaxalone.Metaxalone does not significantly inhibit major CYP enzymes such as CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4. Post marketing experience has not revealed evidence of fetal injury, but such experience cannot exclude the possibility of infrequent or subtle damage to the human fetus.

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