Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite E-3174. Absorption and glucoronidation of the angiotensin II receptor antagonist losartan by the rat intestine. Bioavailability of candesartan is unaffected by food in healthy volunteers administered candesartan cilexitil. Clin Pharmacol Ther 1999; 65: 348–52Meadowcroft AM, Williamson KM, Patterson JH, et al. Merck Research Laboratories, West PointDivision of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USADepartments of Drug Metabolism and Clinical Pharmacology.
The pharmacokinetics of R‐ and S‐warfarin were comparable in the absence and presence of losartan (no significant effects of losartan on area under the curve, C max, or t max). Merck Research Laboratories, West PointDivision of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USADepartments of Drug Metabolism and Clinical Pharmacology. Jpn J Clin Dialysis 1995; 11: 247–64McCrea JB, Lo MW, Furtek CI, et al. Uric acid and losartan (Pt 1). Clin Pharmacol Ther 1997; 62: 417–25Ohtawa M, Takayama F, Saitoh K, et al. N Engl J Med 1996; 334: 1271–2No sources of funding were used to assist in the preparation of this review. Peak concentrations of EXP3174 were reached in 312 hours. Losartan: a review of its use, with special focus on elderly patients. Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers. In these subjects, the average plas … Pharmacotherapy 1996; 16(2 Pt 2): 59–68SHerve F, Urien S, Albengres E, et al. Lancet 2000; 355: 1582–7Dickstein K, Kjekshus J, OPTIMAAL Steering Committee of the OPTIMAAL Study Group. Effects of losartan on a background of hydrochlorothiazide in patients with hypertension.
Merck Research Laboratories, West PointDivision of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USADepartments of Drug Metabolism and Clinical Pharmacology. Am J Hypertens 1995; 8: 1090–8Grossman E, Peleg E, Carroll J, et al. Repeated transient anuria following losartan administration in a patient with a solitary kidney. Overall, losartan has a favorable drug-drug interaction profile, as evidenced by the lack of clinically relevant interactions between this drug and a range of inhibitors and stimulators of the CYP450 system. Cardiology 1996; 87: 569–70Etminan M, Levine MA, Tomlinson G, et al. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Merck Research Laboratories, West PointDivision of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USAUse the link below to share a full-text version of this article with your friends and colleagues. Eur J Neurol 2002; 9: 315Ahmad S. Losartan and severe migraine. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan. Pharmacol Ther 1997; 74: 181–94Martinovic J, Benachi A, Laurent N, et al.
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995–1003Weber MA, Byyny RL, Pratt JH, et al. Hypertension 1993; 21: 704–13Opsahl J, Goldberg MR, Katz SA. Clin Pharmacokinet 2000; 38: 519–26Saruta T, Suzuki H, Kitajima K, et al. 2: S7–15Eberhardt RT, Kevak RM, Kang PM, et al. Clin Pharmacol Ther 1996; 59: 169Williamson KM, Patterson JH, McQueen RH, et al. Curr Opin Nephrol Hypertens 2002; 11: 475–82Shahinfar S, Simpson RL, Carides AD, et al. Pharmacokinetics of intravenous and oral losartan in patients with heart failure. J Allergy Clin Immunol 1996; 98: 471Sharma PK, Yium JJ. The recommended dosage of losartan 50 mg/day can be administered without regard to food. Pharmacokinetics of intravenously and orally administered eprosartan in healthy males: absolute bioavailability and effect of food. Losartan: a study of pharmacovigilance data on 14,522 patients.
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