0 2 Purpose: A new fixed-dose combination (FDC) formulation of telmisartan 80 mg and S-amlodipine 5 mg (CKD-828) has been developed to increase convenience (as only one tablet is required per day) and improve treatment compliance. About two thirds (66.3%) of the patients were male and about 75% were white; the mean age was 53.5 years, and the mean blood pressure at baseline was 153/101 mm Hg. Telmisartan Versus Amlodipine in Patients With Mild-to-Moderate Hypertension The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The full analysis set included patients who had baseline and at least one post baseline trough measure of blood pressure
The treated set (TS) consisted of all patients that took at least one dose of the double-blind treatment (n=1097)
Drug: fixed dose combination of telmisartan+amlodipine Drug: amlodipine: Enrollment 1098 Participant Flow .
1 Call your doctor for medical advice about side effects.
You may also need frequent blood tests.Store at room temperature away from moisture and heat. COVID-19 is an emerging, rapidly evolving situation.
-6.18 Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.This is not a complete list of side effects and others may occur. 2
Estimation Comments
Lowering blood pressure may lower your risk of a stroke or heart attack.Amlodipine and telmisartan may also be used for purposes not listed in this medication guide.You should not use this medicine if you are allergic to amlodipine (Norvasc) or telmisartan (Micardis).You may also need to avoid taking amlodipine and telmisartan with aliskiren You should not breast-feed while you are using this medicine.This medicine is not approved for use by anyone younger than 18 years old. Value: 0.64 The renin‐angiotensin system (RAS) contributes to the pathophysiology of hypertension through the vasoconstrictive and antinatriuretic effects of angiotensin II.
Estimation Comments The full analysis set included patients who had baseline and at least one post baseline trough measure of blood pressure
Full analysis set of patients who had a baseline trough blood pressure measurement and at least one post baseline trough blood pressure measurement using last observation carried forward.
Telmisartan was better tolerated than amlodipine, with a lower incidence of all adverse events and treatment‐related edema compared with the amlodipine group.The effects of 24‐hour blood pressure control on cardiovascular morbidity and mortality have not yet been established, but the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET) will provide important data on the ability of the long‐acting agent telmisartan to reduce cardiovascular morbidity and mortality.
Type: Standard Error of the mean
to -0.14 3 Amlodipine 10mg
For the active ingredient telmisartan + amlodipine. -2.66 The changes in SBP, DBP, and heart rate for the two treatment groups were not significantly different.
After randomization, 81 patients received placebo, 73 patients received telmisartan, and 78 patients received amlodipine. Objective: The aim of this study was to compare the efficacy and safety of telmisartan plus amlodipine with telmisartan plus hydrochlorothiazide for the treatment of uncontrolled hypertension. 0
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Drug information contained herein may be time sensitive. Statistical Test
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