Sci. Key words: acetaminophen, binary mixtures, extended Hildebrand solubility approach, solubility parameter.
The expression was evaluated by Fernandes based on gravimetrically determined solubilities from 10 to 35 °C .
For paracetamol, Granberg and Rasmuson (2000) reported solubility data in mixtures of water and acetone; Romero et al.
So I try to check our algorithm with same data. Metastable zone width (MSZW) experiments were conducted in order to estimate the nucleation kinetics of the system. In this work, pure solvent solubilities of drugs, such as paracetamol, allopurinol, furosemide and budesonide, measured in the temperature range (298.2 - 315.2) K are presented.
K. V. Balakin, N. P. Savchuk, and I. V. Tetko, Curr. In addition, we have determined the experimental solubility by performing turbidity measurements using a Crystal16 over a range of temperatures. Pharmaceutics D. S. Palmer, J. L. McDonagh, J.
Phys. It is widely used as an analgesic and antipyretic.
The solubility of acetaminophen in ethanol + water mixtures (Table 1) was taken from Jiménez and Martínez [5].
ISI
The solubility of active pharmaceutical ingredients (API) needs to be known at different stages of the By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Chem. : Condens. R. T. Ley, G. B. Fuerst, B. N. Redeker, and A. S. Paluch, Ind. K. T. Savjani, A. K. Gajjar, and J. K. Savjani, ISRN Pharm.
The solubility of acetaminophen in ethanol + water + NaCl mixtures at 293.2, 298.2, 303.2, 308.2, and 313.2 K was determined and the results showed that NaCl addition to the solution decreased the solubility.
Sci. Rev.
R. A. Granberg and Å. C. Rasmuson, J. Chem. Prog.
Cited by
(1996) reported data for ethanol–water and ethanol–ethyl acetate binary solvents.
Chem. M. Lísal, W. R. Smith, and J. Kolafa, J. Phys.
Young, H. Jiang, D. Gupta, C. Vega, E. Sanz, P. Debenedetti, and A. Panagiotopoulos, J. Chem.
Fluids F. L. Nordström and Å. C. Rasmuson, Eur. Drug Delivery Rev. Figures
Growth Des. A study of the nucleation kinetics for a cooling crystallisation of paracetamol–ethanol solutions in a batch reactor is described in this paper.
In this investigation, MSZWs were observed to decrease with increased levels of agitation and found to be independent of working volume.We use cookies to help provide and enhance our service and tailor content and ads. The solubility of paracetamol in ethanol was calculated using the following equation: (17) c ⁎ = 2.955 × 10 − 4 exp (2.179 × 10 − 2 T) where T is the temperature measured in Kelvin.
Biomol.
Citations J. Pharm.
A. Oliferenko, P. V. Oliferenko, R. Petrukhin, D. B. Tatham, U. Maran, A. Lomaka, and W. E. Acree, J. Chem. The induction time was observed to be independent of the solution temperature as suggested by Kubota’s theory. Thermodynamics 51 (2012) 172–189, He claimed that PSP can predict solubility of drugs more accurate compare to Hansen Solubility Parameters (HSP).
Phys. M. J. Lazzaroni, D. Bush, C. A. Eckert, T. C. Frank, S. Gupta, and J. D. Olson, Ind.
The solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures at 25 and 30 degrees C was determined using flask shake method. J. Chem. Chem.
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