In clinical trials, the following mean increases were reported in patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat for 96 weeks: fasted total cholesterol increased by 31 and 14 mg/dL, fasted LDL cholesterol by 18 and 7 mg/dL, fasted HDL cholesterol by 7 and 4 mg/dL, fasted triglycerides by 31 and 13 mg/dL.Increased fasting LDL cholesterol (greater than 190 mg/dL) has been reported in 8% and 4% of patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat.
Increased AST (greater than 170 units/L) and ALT (greater than 170 units/L) have been reported in 3% and 2% of females using emtricitabine-tenofovir DF, respectively.Increased AST (greater than 5 x ULN) has been reported in 2% and 2% of patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat.Severe acute exacerbations of hepatitis have been reported in patients with hepatitis B after discontinuation of this drug and were associated with liver failure and liver decompensation in some emtricitabine-treated patients.Hepatic steatosis and hepatitis have also been reported during postmarketing experience with tenofovir DF.Decreased neutrophils (1000 to 1300/mm3: up to 13%; less than 750/mm3: up to 5%) and hemoglobin (8.5 to 10 mg/dL: 4%; less than 9.4 mg/dL: up to 2%) have been reported with emtricitabine-tenofovir DF.Anemia was common in pediatric patients using emtricitabine.-Very common (10% or more): Decreased neutrophils (up to 13%)-Common (1% to 10%): Sinusitis, upper respiratory tract infections, nasopharyngitis-Very common (10% or more): Rhinitis, increased coughIncreased serum amylase (greater than 175 units/L) has been reported in up to 8% of patients using emtricitabine-tenofovir DF.In clinical trials, nausea was the most common side effect reported in antiretroviral therapy-naive HIV-1-infected patients using emtricitabine plus tenofovir alafenamide with elvitegravir plus cobicistat.Increased amylase (greater than 2 x ULN) has been reported in 2% and 4% of patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat.-Common (1% to 10%): Diarrhea, nausea, abdominal pain (included abdominal pain, upper abdominal pain, lower abdominal pain, gastrointestinal pain, abdominal discomfort)-Common (1% to 10%): Diarrhea, nausea, increased serum amylase, abdominal pain (included abdominal pain, upper abdominal pain, lower abdominal pain, gastrointestinal pain, abdominal discomfort), vomiting-Common (1% to 10%): Diarrhea, vomiting, abdominal pain, flatulence, increased amylase-Very common (10% or more): Diarrhea, nausea, abdominal pain-Common (1% to 10%): Increased amylase (including increased pancreatic amylase), increased serum lipase, vomiting, dyspepsia-Very common (10% or more): Diarrhea, vomiting, nauseaIn clinical trials of HIV-1-uninfected individuals, decreased BMD was reported.
"Antiretroviral prophylaxis for HIV prevention in heterosexual men and women." Ototoxic medications are those that are toxic to the cochlea or vestibular (balance) structures in the ear.These medications have the potential to cause hearing loss, tinnitus and/or dysequilibrium such as dizziness and vertigo.
There are many other medications that have been listed as potentially ototoxic.In his excellent article, “What you should know about ototoxic medications,” published in Dr. Epstein advises that if any of these symptoms develop while taking any medication, stop the medication immediately and call your doctor.Just as each of us is ultimately responsible for our own health, those of us with tinnitus must be particularly careful of medications that may cause our condition to worsen. Most people tolerate the drug well, however, and any side effects that do occur are generally mild.
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