They included three fluoroquinolone-based oral combinations (levofloxacin plus rifampin, levofloxacin plus clindamycin, ciprofloxacin plus amoxicillin-clavulanate) [HVO was classified as community-acquired or healthcare-associated HVO according to published criteria [Categorical variables are expressed as numbers and percentages and were compared by χ2 or Fisher’s exact test. The most frequently isolated organisms were methicillin-susceptible There were some differences in the proportions of pathogens between community-acquired HVO and healthcare-associated HVO. Prediction‐corrected visual checks were used as informative diagnostic tools to allow inspection of model appropriateness across time as well as across covariate values The most common causative organism of osteomyelitis in adults is A total of 50 patients and 122 plasma concentrations were available for pharmacokinetic evaluation and statistical analysis, 22 patients received clindamycin orally and 22 intravenously. • Clindamycin pharmacokinetics have been studied in adult patients. : principes et modalitésPharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and menA Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay?, Recommendations for Systemic Antimicrobial Therapy in Fracture-Related Infection, Pregnancy‐related pharmacokinetics and antimicrobial prophylaxis during fetal surgery, cefazolin and clindamycin as examples, First dose in neonates: pharmacokinetic bridging study from juvenile mice to neonates for drugs metabolized by CYP3A, Use of normalized prediction distribution errors for assessing population physiologically-based pharmacokinetic model adequacy, Feasibility of early switch to oral antibiotic in brain abscesses and empyema: a multicentre retrospective study, European Journal of Clinical Microbiology & Infectious Diseases, Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools, Picking the low‐hanging fruit: Why not choose oral antibiotics for skin and soft‐tissue infections in the emergency department, Pharmacology of Antimalarial Drugs, Current Anti-malarials, Influence of antibiotic treatment on the detection of S. aureus in whole blood following pathogen enrichment, Bioavailability Testing of a Newly Developed Clindamycin Oral Suspension in a Pediatric Porcine Model, Dosing strategies to optimize currently available anti-MRSA treatment options (Part 2: PO options), Clinical outcomes in patients hospitalized with cellulitis treated with oral clindamycin and trimethoprim/sulfamethoxazole: The role of weight-based dosing, Efficacy of intramuscular moxifloxacin in the treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus, Obesity and Heart Failure as Predictors of Failure in Outpatient Skin and Soft Tissue Infections, Pharmacokinetics of Clindamycin in Obese and Nonobese Children, HLA-B*51:01 is strongly associated with clindamycin-related cutaneous adverse drug reactions, Integrated pharmacokinetic–pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery, Clindamycin and rifampicin: No bull's eye without a target, Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants, Arrgh, having a nightmare ... am on 20mg of citalopram a day but have developed a MAJOR tooth infection and need root canal treatment.
Pharm World Sci … In case reports, metronidazole has been found to cure anaerobic osteomyelitis, including as salvage therapy after failure of clindamycin or cephalosporin therapy .
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