m very concerned about taking iron, even though the hematologist told me to. Restless legs syndrome (RLS) appears to have some mechanism creating a ‘hyperarousal’ phenomenon in such a way that despite producing profound chronic sleep loss there is no significant daytime sleepiness. They're benign and unknown cause, magnesium deficiency? I guess iron was the fix! Until more is known, 5-HTP should be used cautiously. I’ve had this in the past, but not to this severity. Everything I read online says that low stomach acid & RLS is that it prevents B12, iron, & other mineral absorption, causing deficiencies linked to RLS. Apparently the Benadryl was causing it, so I stopped Benadryl and haven't had restless legs since. But some people who have taken 5-HTP have developed a condition called eosinophilia-myalgia syndrome (EMS). But... NOW I CAN'T SLEEP. Diphenhydramine (also known as DPH, Benadryl, and many others) is a deliriant substance of the ethanolamine class. I would think the 5htp would tear up your stomach? As 5-HTP is precursor of serotonin and occurs naturally in our food (tryptophan is metabolized to 5-HTP), the only question is which dosage is safe. In tapering off the mirtazapine, my symptoms have become much worse. So yes, I would recommend a cautious approach (I also experience a lot of rare side effects). Now to try to remember to have these tests ran: I had some beef the other day and definitely the restless feeling went away.

But there's not enough scientific evidence to know if EMS is caused by 5-HTP, a contaminant, or some other factor. EMS is a serious condition involving extreme muscle tenderness (myalgia) and blood abnormalities (eosinophilia). Maybe you mistook it for betain HCL? I know B1 from ME treatment, some doctors will give 300mg Benfothiamine a day and some patients see improvement ( this includes not taking meds such as Tylenol PM or Advil PM that list diphenhydramine as an ingredient. Anyone have this too? This may be overstimulating for some people, but for me this stimulation actually helps my legs calm down.

It’s one of the most used supplements in the U.S. I’m not on a salt restriction diet, so no reason to fool around and become deficient. I still think that it's a mixup and you have read about something else. Although the RL is better, overall I feel worse, stomach pain and reflux. Really, who knows?It has some iodine. Doesn’t seem to bother in bed or sleeping. It interrupted my sleep and kept my husband awake too.I’m beginning to wonder what I have. So now in re reading this thread, I get the reminder of LDN. Millions of Americans take melatonin to fall asleep. But as far as supplements go I'd rate 5-HTP as "as safe as it gets". I’ve always been afraid to try it, as I’ve read that it’s very acidic and therefore harsh on the stomach. I’m beginning to wonder what I have. Regular, moderate exercise may help you sleep better.

Nothing is stopping it yet. For depression treatment, dosages up to 1000mg 3x daily (up to 3 grams) have been reported. Anyone have this too? I don't know if this is for you, but I've used a brush to help manage restless leg syndrome. You might mix up something here. There was an obvious reason why I never took it after my husband bought it for me.There is no indication that the 5-HTP itself caused a disease. And a lot of muscle twitches.

Ok now that I have that prescription issue resolved... And a lot of muscle twitches. Hi Eddie.....For all I can remember, that may be the very reason I didn't take it. 5-HTP is a precursor of serotonine and produced naturally in a healty gut, why should it tear up your stomach? I’m not on a salt restriction diet, so no reason to fool around and become deficient. Take a walk with the kids, the dog, or a friend. That is, there is always a small risk of adverse reactions, and we ME patients tend to win in the side effect lottery. You must log in or register to reply here. The restless leg/twitching, which I expected to go away, has continued, despite the reduced dose. I drink a lot of water, so I’m going to get serious about keeping up. But... NOW I CAN'T SLEEP. “Patients with restless legs syndrome (RLS) already have difficulty sleeping as their symptoms tend to worsen at night or with rest, but sedating antihistamines, such as Benadryl, can intensify the symptoms,” says Dr. William Ondo. When exceeding approved doses, diphenhydramine produces powerful deliriant effects. Apparently the Benadryl was causing it, so I stopped Benadryl and haven't had restless legs since. Re: benadryl help When I did his first Diphenhydramine (Benadryl) experiments, SWIM weighed close to what you weigh, and from SWIM's experience 250mgs has the following effects.. Heavyness in legs; Extreme dry-mouth; A constant feeling for tiredness; Inability to sleep despite being extremely tired; Small objects have the potential to appear to be moving and/or grow legs … That's a fairly low dose even though it doen't sound like it.

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