Patients with congestive The hemodynamic response to nitroglycerin administration, to sublingual or oral administration These data demonstrate that the duratioa of the bemodvnamic effects of sublingually and orally admin istered lsosorbide dinitrate In patients with unstable an gina pectoris and normal resting hemodynamics is 8 to 12 times longer than that of nitroglycerin. Isosorbide mononitrate is in the class of drugs called nitrates that are used for treating and preventing angina.Other nitrates include nitroglycerin (Nitrostat, NitroQuick, Nitrolingual, Nitro-Dur and others) and isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron).Nitrates are vasodilators (dilators of blood vessels). dinitrate were small and not significant In the group receiving isosorbide dinitrate Effects of nitroglycerin.Effects of nitroglycerin on left ventricular volumes and wall tension in patients with ischemic heart disease.Left ventricular volume changes after amyl nitrite and nitroglycerin in man as measured by ultrasound.Nitroglycerin to unmask reversible asynergy: Correlation with post coronary bypass ventriculography.The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm.Hemodynamic effects of nitroglycerin in patients with angina pectoris studied by an atrial pacing method.Myocardial blood flow in coronary artery disease: Effect of right atrial pacing and nitroglycerin.Left ventricular pressure-volume relationships during myocardial ischemia in man.The therapeutic role of coronary vasodilators: Glyceryl trinitrate, isosorbide dinitrate and pentaerythritol and pentaerythritol tetranitrate.Sublingual dinitrate therapy versus sublingual placebo in angina pectoris.Comparative evaluation of sublingual long-acting nitrates.Effects of propranolol and isosorbide dinitrate on exercise performance and adrenergic activity in patients with angina pectoris.Clinical and circulatory effects of isosorbide dinitrate: Comparison with nitroglycerin.The long acting hemodynamic effects of isosorbide dinitrate.Hemodynamic effects of orally administered isosorbide dinitrate in patients with congestive heart failure.The computer as an integral part of hemodynamic monitoring.Ventricular volumes and ejection function by echocardiography.Equations for the calculation of mean ejection pressure.Early sequential changes in left ventricular dimensions and filling pressure in post myocardial infarction patients.Determination of left ventricular preload and afterload using quantitative echocardiography in man: Calibration of the method.Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction.© 1976 The American College of Chest Physicians.
The major drawback of their therapeutic use is the rapid development of tolerance. Patients with congestive heart failure were not included in this study.
1977 Feb;55(2):381-7. doi: 10.1161/01.cir.55.2.381.Am J Cardiol. Elsevier Science To read this article in full you will need to make a paymentEffect of nitroglycerin on the coronary circulation in patients with coronary artery disease or increased left ventricular work.The effect of nitroglycerin on coronary circulation in man and dog: Myocardial blood flow measured with xenonEffects of nitroglycerin on regional myocardial blood flow in coronary artery disease.Studies on cardiac dimensions in intact unanesthetized man: 5. These data demonstrate that the duration of the hemodynamic effects of sublingually and orally administered isosorbide dinitrate in patients with unstable angina pectoris and normal resting hemodynamics is 8 to 12 times longer than that of nitroglycerin. Isosorbide mononitrate has one nirate group and isosorbide dinatrate has 2 nitro groups.
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