0000111720 00000 n In: Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins. Food and Drug Administration. Drugs may be metabolized by only one CYP450 enzyme (e.g., metoprolol by CYP2D6) or by multiple enzymes (e.g., warfarin [Coumadin] by CYP1A2, CYP2D6, and CYP3A4).Amiodarone (Cordarone), cimetidine (Tagamet), ciprofloxacin (Cipro), fluvoxamine (Luvox‡)Carbamazepine (Tegretol), phenobarbital, rifampin (Rifadin), tobaccoAmiodarone, fluconazole (Diflucan), fluoxetine (Prozac), metronidazole (Flagyl), ritonavir (Norvir), trimethoprim/sulfamethoxazole (Bactrim, Septra)Carbamazepine, phenobarbital, phenytoin (Dilantin), rifampinCarvedilol (Coreg), celecoxib (Celebrex), glipizide (Glucotrol), ibuprofen (Motrin), irbesartan (Avapro), losartan (Cozaar)Amiodarone, cimetidine, diphenhydramine (Benadryl), fluoxetine, paroxetine (Paxil), quinidine, ritonavir, terbinafine (Lamisil)Amitriptyline, carvedilol, codeine, donepezil (Aricept), haloperidol (Haldol), metoprolol (Lopressor), paroxetine, risperidone (Risperdal), tramadol (Ultram)Clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin, grapefruit juice, itraconazole (Sporanox), ketoconazole (Nizoral), nefazodone (Serzone‡), ritonavir, telithromycin (Ketek), verapamil (Calan)Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)Amiodarone (Cordarone), cimetidine (Tagamet), ciprofloxacin (Cipro), fluvoxamine (Luvox‡)Carbamazepine (Tegretol), phenobarbital, rifampin (Rifadin), tobaccoAmiodarone, fluconazole (Diflucan), fluoxetine (Prozac), metronidazole (Flagyl), ritonavir (Norvir), trimethoprim/sulfamethoxazole (Bactrim, Septra)Carbamazepine, phenobarbital, phenytoin (Dilantin), rifampinCarvedilol (Coreg), celecoxib (Celebrex), glipizide (Glucotrol), ibuprofen (Motrin), irbesartan (Avapro), losartan (Cozaar)Amiodarone, cimetidine, diphenhydramine (Benadryl), fluoxetine, paroxetine (Paxil), quinidine, ritonavir, terbinafine (Lamisil)Amitriptyline, carvedilol, codeine, donepezil (Aricept), haloperidol (Haldol), metoprolol (Lopressor), paroxetine, risperidone (Risperdal), tramadol (Ultram)Clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin, grapefruit juice, itraconazole (Sporanox), ketoconazole (Nizoral), nefazodone (Serzone‡), ritonavir, telithromycin (Ketek), verapamil (Calan)Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)Additionally, a drug can be both metabolized by and inhibit the same enzyme (e.g., erythromycin), or it can be metabolized by one enzyme and inhibit another enzyme (e.g., terbinafine [Lamisil]).Inducers increase CYP450 enzyme activity by increasing enzyme synthesis. Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures. Pharmacodynamic Interactions .
This is because drug metabolism via CYP450 enzymes exhibits genetic variability (polymorphism) that influences a patient's response to a particular drug.A specific gene encodes each CYP450 enzyme. <<9B09FE44D8B0194DB4F82B9A5010D8B0>]>> • Vaginal preparations have also been reported to interact with alcohol.
Roche AmpliChip cytochrome P450 genotyping test and Affymetrix GeneChip Microarray Instrumentation System—K042259. 0000021531 00000 n
TheThe mechanism of the interaction between amiodarone and warfarin in humans. Weinshilboum R. See Also References ↑ Dialysis of Drugs. Identify these contraindicated and dangerous rivaroxaban oral (Xarelto Oral) drug combinations to avoid with the RxList drug interaction checker tool. Slaughter RL, Recent advances: the cytochrome P450 enzymes. 0000002642 00000 n Forslund-Bergengren C, Orme M. Bailey DG. 0000010180 00000 n �����>��5͢����%^3�Z�����qatrj���p�|��F�������4r�d
If you've had an allergic reaction to Bactrim, it doesn't mean you need to avoid other sulfa-containing medications.
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