In the Phase III pivotal studies, analysis of the primary efficacy endpoint demonstrated that Duobrii was statistically significantly more effective than Vehicle Lotion in achieving treatment success in the Investigator's Global Assessment (IGA) at Week 8, defined as at least a 2-grade improvement from Baseline and a score of Clear or Almost Clear in both studies.In the first study 35.76% of subjects in the DUOBRII group had treatment success at Week 8 compared with 6.98% in the Vehicle group. When halobetasol propionate and tazarotene are administered together in DUOBRII, they provide complementary effects due to their individual modes of action targeting different receptors and pathways to achieve anti-inflammatory control and epidermal morphologic restoration. "Psoriasis is a common, chronic, and life-altering skin condition that affects approximately one million Canadians, with 90% of those affected suffering from plaque psoriasis.The disease is characterized by red elevated patches and flaking silvery scales, and symptoms can range from mild to severe. The improvement that is seen in psoriatic patients appears to occur in association with the restoration of normal cutaneous morphology and the reduction of the inflammatory markers ICAM-1 and HLA-DR.DUOBRII is also distinct based on its Prismatrex™ technology, a polymeric emulsification system which provides a stable condition where emulsion droplets retained their distribution across time and temperature.The clinical efficacy and safety of once daily use of DUOBRII were assessed in two prospective, multi-centre, randomized, double-blind Phase III clinical trials in subjects 18 years and older with moderate to severe plaque psoriasis. The fact that it is the only Health Canada-approved drug for psoriasis to provide extended clearance post-treatment is an important benefit. Psoriasis is a chronic condition, which means that patients need continuous solutions to manage their symptoms. These well-known ingredients have long-established efficacy profiles. White blood cells (T cells) in the immune system are triggered and this causes inflammation to occur, which then causes skin cells to rise to the surface and shed at 10 times the normal rate.In Canada, the Company's prescription product portfolio is focused on eye health, dermatology, and cardio-metabolic conditions. In addition to the tremendous medical burden experienced while trying to find a medication that controls the disease, the psychological impact is high.

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"We know how difficult psoriasis is to treat and it is even harder to live with for patients and their families," said DUOBRII lotion provides the combined action of two unrelated compounds, halobetasol propionate, a corticosteroid, and tazarotene, a retinoid prodrug. LAVAL, QC, Aug. 11, 2020 /PRNewswire/ -- Bausch + Lomb, a leading global eye health business of Bausch Health Companies Inc. (NYSE/TSX: BHC) ("Bausch Health"), today announced that it has received approval from Health Canada for the sale of BAUSCH + LOMB ULTRA ® ONE DAY daily disposable silicone hydrogel (SiHy daily) contact lenses.. BAUSCH + LOMB ULTRA ® ONE DAY contact … Helping people see better to live better since 1853. A Cision company. Psoriasis develops when there is a malfunctioning of the immune system which causes inflammation. "We know how difficult psoriasis is to treat and it is even harder to live with for patients and their families," said DUOBRII lotion provides the combined action of two unrelated compounds, halobetasol propionate, a corticosteroid, and tazarotene, a retinoid prodrug. "Offering my patients a new option with promising, long-term results will help deliver what every psoriasis patient hopes for: achieving clear skin. Bausch Health, Canada Inc. June 16, 2020 p.13. White blood cells (T cells) in the immune system are triggered and this causes inflammation to occur, which then causes skin cells to rise to the surface and shed at 10 times the normal rate.In Canada, the Company's prescription product portfolio is focused on eye health, dermatology, and cardio-metabolic conditions. When halobetasol propionate and tazarotene are administered together in DUOBRII, they provide complementary effects due to their individual modes of action targeting different receptors and pathways to achieve anti-inflammatory control and epidermal morphologic restoration. "Psoriasis is a common, chronic, and life-altering skin condition that affects approximately one million Canadians, with 90% of those affected suffering from plaque psoriasis.The disease is characterized by red elevated patches and flaking silvery scales, and symptoms can range from mild to severe. West Laval, Quebec H7L 4A8 Canada (800) 361-1448 LAVAL, QC, Sept. 2, 2020 /CNW Telbec/ - Bausch Health, Canada, part of Bausch Health Companies Inc. (NYSE: BHC) (TSX: BHC), ("Bausch Health" or the "Company") today announced that its novel topical prescription drug for improving the signs and symptoms of plaque psoriasis in adult patients is now available in Canada. Welcome to the official home page of Bausch + Lomb Canada - the largest global provider of eye care products. Psoriasis often impacts nearly every aspect of an individual's life including their ability to work and maintain social and intimate relationships. LAVAL, QC, Sept. 2, 2020 /CNW Telbec/ - Bausch Health, Canada, part of Bausch Health Companies Inc. (NYSE: BHC) (TSX: BHC), ("Bausch Health" …

In the Phase III pivotal studies, analysis of the primary efficacy endpoint demonstrated that Duobrii was statistically significantly more effective than Vehicle Lotion in achieving treatment success in the Investigator's Global Assessment (IGA) at Week 8, defined as at least a 2-grade improvement from Baseline and a score of Clear or Almost Clear in both studies.In the first study 35.76% of subjects in the DUOBRII group had treatment success at Week 8 compared with 6.98% in the Vehicle group. When halobetasol propionate and tazarotene are administered together in DUOBRII, they provide complementary effects due to their individual modes of action targeting different receptors and pathways to achieve anti-inflammatory control and epidermal morphologic restoration. "Psoriasis is a common, chronic, and life-altering skin condition that affects approximately one million Canadians, with 90% of those affected suffering from plaque psoriasis.The disease is characterized by red elevated patches and flaking silvery scales, and symptoms can range from mild to severe. The improvement that is seen in psoriatic patients appears to occur in association with the restoration of normal cutaneous morphology and the reduction of the inflammatory markers ICAM-1 and HLA-DR.DUOBRII is also distinct based on its Prismatrex™ technology, a polymeric emulsification system which provides a stable condition where emulsion droplets retained their distribution across time and temperature.The clinical efficacy and safety of once daily use of DUOBRII were assessed in two prospective, multi-centre, randomized, double-blind Phase III clinical trials in subjects 18 years and older with moderate to severe plaque psoriasis. The fact that it is the only Health Canada-approved drug for psoriasis to provide extended clearance post-treatment is an important benefit. Psoriasis is a chronic condition, which means that patients need continuous solutions to manage their symptoms. These well-known ingredients have long-established efficacy profiles. White blood cells (T cells) in the immune system are triggered and this causes inflammation to occur, which then causes skin cells to rise to the surface and shed at 10 times the normal rate.In Canada, the Company's prescription product portfolio is focused on eye health, dermatology, and cardio-metabolic conditions. In addition to the tremendous medical burden experienced while trying to find a medication that controls the disease, the psychological impact is high.

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