Manufacturer advises avoid—toxicity in animal studies. Available for Android and iOS devices. Select one or more newsletters to continue.
8%] of 5275 A National Strategy and Broad Plan of Action for the Prevention and Control of Anaemia in Pregnancy. Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population studyAccess any 5 articles from the Lancet Family of journalsHookworm infection and anaemia: approaches to prevention and control. Contact Breast feeding ... Mebendazole tablets can be sold to the public if supplied for oral use in the treatment of enterobiasis in adults and children over 2 years provided its container or package is labelled to show a max. in developing countries, where intestinal helminthiases are endemic.
At present, however, this is not a widely accepted control strategy because of a lack of data on the safety of the drug. Untreated soil-transmitted helminth infections in pregnancy are associated with adverse outcomes (including maternal iron deficiency anemia, low birth weight, neonatal and maternal death).
Background In areas endemic for hookworm, routine antenatal mebendazole therapy could greatly reduce the prevalence of anaemia in pregnancy. Report of the WHO Informal Consultation on hookworm infection and anaemia in girls and women. We assessed the effect of mebendazole therapy during pregnancy on birth outcome. the first trimester. Pregnancy. There are no controlled data in human pregnancy; however, this drug has been used during pregnancy without evidence of fetal harm.Limited data suggest this drug is poorly excreted into breast milk and poorly absorbed orally. This drug should be used during pregnancy only if the benefit outweighs the risk.Animal studies have revealed evidence of embryofetal toxicity and teratogenicity; in rats, adverse developmental effects (i.e., skeletal malformations, soft tissue malformations, decreased pup weight, embryolethality) were observed when single oral doses as low as 10 mg/kg (about 0.5-fold [100 mg] or 0.2-fold [500 mg] the maximum recommended human dose) were administered during organogenesis. in major congenital defects, but our results indicate that it should be avoided during Studies of a small number of pregnant women taking mebendazole in early pregnancy have shown no link with miscarriage. Reports regarding use of this drug during breastfeeding have shown no adverse effects in breastfed infants; rare cases of decreased milk production reported after use of this drug, but no compelling proof that such cases were due to this drug.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A study of around 2,500 pregnant women taking mebendazole did not shown any links with stillbirth, premature delivery (before 37 weeks of pregnancy), very low birth weight in the baby (less than 1,500g), or the baby dying soon after birth. We comply with the HONcode standard for trustworthy health information - However if you have another worm infection such as roundworm or hookworm, you should speak to a doctor to discuss the best way to treat this. There are no controlled data in human pregnancy; however, this drug has been used during pregnancy without evidence of fetal harm. To read this article in full you will need to make a paymentManagement of threadworm infestation during pregnancy.Mebendazole for worming mice: effectiveness and side effects.Embryotoxic and antimitotic properties of some benzimidazole related compounds.Evaluation of effectiveness of ironfolate supplementation and anthelminthic therapy against anemia in pregnancy—a study in the plantation sector of Sri Lanka.The prevalence and control of soil-transmitted nematode infections among children and women in the plantations in Sri Lanka.A study of major birth defects seen at a general hospital.Anthelmintics: a comparative review of their clinical pharmacology. Mebendazole isn't usually recommended for the treatment of threadworms during pregnancy or when breastfeeding. This therapy could offer beneficial effects to pregnant women Mebendazole has shown embryotoxic and teratogenic activity in pregnant rats and mice at oral doses of 10 mg/kg/day and above and in rats at a single dose of 10 mg/kg, approximately equivalent to the human dose of 100 mg on a body surface area (mg/m 2) basis. Mebendazole therapy during pregnancy is not associated with a significant increase
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