Thus, fluoxetine may be administered with or without food.Over the concentration range from 200 to 1000 ng/mL, approximately 94.5% of fluoxetine is bound in vitro to human serum proteins, including Fluoxetine is a racemic mixture (50/50) of R-fluoxetine and S-fluoxetine enantiomers. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Ciprodar contraindications; Additional information about Ciprodar; Ciprodar - General Information .
Although some patients achieved freedom from binge-eating and purging as a result of treatment, for the majority, the benefit was a partial reduction in the frequency of binge-eating and purging.In a longer-term trial, 150 patients meeting DSM-IV criteria for Bulimia Nervosa, purging subtype, who had responded during a The effectiveness of PROZAC in the treatment of Panic Disorder was demonstrated in 2 double-blind, randomized, placebo-controlled, multicenter studies of adult outpatients who had a primary diagnosis of Panic Disorder (DSM-IV), with or without agoraphobia.Study 1 (N=180 randomized) was a 12-week flexible-dose study. However, adverse effects on fertility were seen when juvenile rats were treated with fluoxetine [seeWhen using PROZAC and olanzapine in combination, also refer to the Use in Specific Populations section of the package insert for Symbyax.There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants during pregnancy. However, many people have no side effects or only have minor side effects. While a specific study with pimozide and fluoxetine has not been conducted, the potential for drug interactions or QT prolongation warrants restricting the concurrent use of pimozide and PROZAC [seeThioridazine should not be administered with PROZAC or within a minimum of 5 weeks after PROZAC has been discontinued, because of the risk of QT Prolongation [see In a study of 19 healthy male subjects, which included 6 slow and 13 rapid hydroxylators of debrisoquin, a single 25 mg oral dose of thioridazine produced a 2.4-fold higher Cmax and a 4.5-fold higher AUC for thioridazine in the slow hydroxylators compared with the rapid hydroxylators. After one week, increase the dose to 20 mg/day. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anti-coagulants may add to this risk. In particular, some evidence suggests that SSRIs can cause such untoward sexual experiences. These data indicate that fluoxetine's extent of inhibition of CYP3A4 activity is not likely to be of clinical significance.Fluoxetine (60 mg single dose or 60 mg daily dose for 8 days) causes a small (mean 16%) increase in the maximum concentration of olanzapine and a small (mean 16%) decrease in olanzapine clearance. After 1 week at 10 mg/day, increase the dose to 20 mg/day. In these clinical trials, only a primary reaction associated with discontinuation was collected.Although changes in sexual desire, sexual performance, and sexual satisfaction often occur as manifestations of a psychiatric disorder, they may also be a consequence of pharmacologic treatment. While the premarketing clinical experience with PROZAC did not reveal any tendency for a withdrawal syndrome or any drug seeking behavior, these observations were not systematic and it is not possible to predict on the basis of this limited experience the extent to which a CNS active drug will be misused, diverted, and/or abused once marketed. PROZAC should be discontinued before initiating treatment with the MAOI [see If concomitant use of PROZAC with other serotonergic drugs, i.e., triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, amphetamines, and St. John’s Wort is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases.Treatment with PROZAC and any concomitant serotonergic agents, should be discontinued immediately if the above events occur and supportive In US fluoxetine clinical trials, 7% of 10,782 patients developed various types of rashes and/or In premarketing clinical trials, 2 patients are known to have developed a serious Since the introduction of PROZAC, systemic reactions, possibly related to vasculitis and including Pulmonary reactions, including inflammatory processes of varying histopathology and/or fibrosis, have been reported rarely.
A reaction was considered treatment-emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation.Incidence In Major Depressive Disorder, OCD, Bulimia, And Panic Disorder Placebo-Controlled Clinical Trials (excluding data from extensions of trials)Table 3 enumerates the most common treatment-emergent adverse reactions associated with the use of PROZAC (incidence of at least 5% for PROZAC and at least twice that for placebo within at least 1 of the indications) for the treatment of Major Depressive Disorder, OCD, and bulimia in US controlled clinical trials and Panic Disorder in US plus non-US controlled trials. The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients. For some patients it may be advisable to titrate up to this target dose over several days.
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