Purpose: In patients with hormone-dependent postmenopausal breast cancer, standard adjuvant therapy involves 5 years of the nonsteroidal aromatase inhibitors anastrozole and letrozole.
This review summarizes the available evidence regarding known differences and evaluates their potential clinical impact.Breast cancer is the most common cancer among women worldwide [The evolution of AIs has seen the transition from prototype agents that were either not particularly potent or selective to third‐generation drugs that are considerably more potent and specific. La survie sans maladie est définie comme étant la première survenue de récidive locale ou à distance, de cancer du sein controlatéral ou de décès de toute cause.b.
i do hope all yours have now settled.I very much hope things have improved for you, Grannyatti.I have just come across this thread as my mum started on exemestane a week ago and has just started to feel sick and is constipated.
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Epub 2017 May 2.Llombart-Cussac A, Ruiz A, Antón A, Barnadas A, Antolín S, Alés-Martínez JE, Alvarez I, Andrés R, García Saenz JA, Lao J, Carrasco E, Cámara C, Casas I, Martín M.Cancer. I feel hot and feverish all the time rather than having hot flushes.My oncologist suggests I take the tablets for another three or four weeks to see if things improve and if not, go back on Tamoxifen.I am just wondering what other people have experienced?
Effect of 7‐alpha‐methyl‐19‐nortestosterone acetate and testosterone propionate on clinical course and hormonal excretionRole of androgens on MCF‐7 breast cancer cell growth and on the inhibitory effect of letrozole5Alpha‐reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen productionEffects of aromatase inhibitors on human osteoblast and osteoblast‐like cells: A possible androgenic bone protective effects induced by exemestaneEffects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized ratsThe steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized ratsSkeletal effects of exemestane on bone‐mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): A randomized controlled studyEffects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancerChanges in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2‐year treatment with exemestane: A randomised, placebo‐controlled studyEffects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal womenComplete data from the letrozole (L), exemestane (E), and anastrozole (A) pharmacodynamic (PD) ‘LEAP’ trial: Direct comparison of safety parameters between aromatase inhibitors (AIs) in healthy postmenopausal women [abstract]Phase II study of sequential hormonal therapy with anastrozole/exemestane in advanced and metastatic breast cancerIs there a benefit by the sequence anastrozole‐formestane for postmenopausal metastatic breast cancer women?Aromatase inhibition with 4‐OHAndrostenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancerThird‐line hormonal treatment with exemestane in postmenopausal patients with advanced breast cancer progressing on aminoglutethimide: A phase II multicentre multinational studyActivity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: A phase II trialFormestane, a steroidal aromatase inhibitor after failure of non‐steroidal aromatase inhibitors (anastrozole and letrozole): Is a clinical benefit still achievable?The estrogen suppression after sequential treatment with formestane in advanced breast cancer patientsSequential treatment with exemestane and non‐steroidal aromatase inhibitors in advanced breast cancerThird‐line hormonal treatment with exemestane in postmenopausal patients with advanced breast cancer progressing on letrozole or anastrozole.
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