Drowsiness, dizziness, lightheadedness, blurred vision, constipation, or dry mouth may occur. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvb25maS1zeW1wYXphbi1jbG9iYXphbS05OTk2OTY= 1186482-overview CYP2C19 poor metabolizers. In order for us to best serve you and provide you with the best information, can you please tell us if you currently have health insurance? Click

dosage should not exceed 40 mg per day. Compazine (prochlorperazine) is a prescription medication used to control nausea and vomiting, and is used as an antipsychotic medication for schizophrenia and psychotic disorders. Visit cvs.com …

Diseases & Conditions Indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS)Initiate at 5 mg PO q12hr; may titrate as tolerated up to 40 mg/day divided q12hrDose escalation should not proceed more rapidly than once weeklyIndicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years or olderPlasma concentrations at any given dose are generally higher in the elderly; proceed slowly with dose escalationStarting dose should be 5 mg/day for all elderly patients and titrated according to weight, but to half the typical adult doseAdditional titration to the maximum daily dose (depending on weight either 20 mg/day or 40 mg/day) may be started on day 21Administer daily doses >5 mg in divided doses q12hrBlood Disorders: Anemia, eosinophilia, leukopenia, thrombocytopeniaRespiratory Disorders: Aspiration, respiratory depressionSkin and Subcutaneous Tissue Disorders: Rash, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), urticariaConcomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death; administer concomitantly when there are no alternative options; limit dosages and durations to minimum required; monitor for signs and symptoms of respiratory depression and sedationSomnolence or sedation; generally occurs within the first month of treatment and may diminish with continued treatment; caution patients about operating hazardous machinery, including automobiles, until they are reasonably certain that therapy does not affect them adversely (eg, impair judgment, thinking or motor skills)Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) reported in both children and adults; monitor closely, especially during the first 8 weeks of treatment initiation or when reintroducing therapy; discontinue at the first sign of drug-related rash and do not resume unless rash is clearly not drug related; if signs or symptoms suggest SJS/TEN, do not resume therapy; alternative therapy should be consideredConsider history of substance abuse because of predisposition of such patients to physical and/or psychological dependence; patients with history of substance abuse should be under careful surveillance when receiving drug or other psychotropic agents because of predisposition of such patients to habituation and dependencePatients treated with any antiepileptic drug for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior; should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether emergence of these symptoms in any given patient may be related to illness being treated; behaviors of concern should be reported immediately to healthcare providersEncourage pregnant patients (or their caregivers) to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry; toll free number 1-888-233-2334; http://www.aedpregnancyregistry.orgThere are no adequate and well-controlled studies in pregnant women; available data suggest that the class of benzodiazepines is not associated with marked increases in risk for congenital anomalies; although some early epidemiological studies suggested a relationship between benzodiazepine drug use in pregnancy and congenital anomalies such as cleft lip and or palate, these studies had considerable limitations; more recently completed studies of benzodiazepine use in pregnancy have not consistently documented elevated risks for specific congenital anomalies; there is insufficient evidence to assess effect of benzodiazepine pregnancy exposure on neurodevelopmentThere are clinical considerations regarding exposure to benzodiazepines during second and third trimester of pregnancy or immediately prior to or during childbirth; these risks include decreased fetal movement and/or fetal heart rate variability, “floppy infant syndrome,” dependence, and withdrawalAdministration of clobazam to pregnant rats and rabbits during period of organogenesis or to rats throughout pregnancy and lactation resulted in developmental toxicity, including increased incidences of fetal malformations and mortality, at plasma exposures for clobazam and its major active metabolite, N-desmethylclobazam, below those expected at therapeutic doses in patients; data for other benzodiazepines suggest possibility of long-term effects on neurobehavioral and immunological function in animals following prenatal exposure to benzodiazepines at clinically relevant doses; drug should be used during pregnancy only if potential benefit to mother justifies potential risk to fetus; advise a pregnant woman and women of childbearing age of potential risk to a fetusInfants born to mothers who have taken benzodiazepines during later stages of pregnancy can develop dependence, and subsequently withdrawal, during postnatal period; clinical manifestations of withdrawal or neonatal abstinence syndrome may include hypertonia, hyperreflexia, hypoventilation, irritability, tremors, diarrhea, and vomiting; these complications can appear shortly after delivery to 3 weeks after birth and persist from hours to several months depending on degree of dependence and pharmacokinetic profile of the benzodiazepine; symptoms may be mild and transient or severe; standard management for neonatal withdrawal syndrome has not yet been defined; observe newborns who are exposed to drug in utero during later stages of pregnancy for symptoms of withdrawal and manage accordinglyDrug is excreted in human milk; postmarketing experience suggests that breastfed infants of mothers taking benzodiazepines, may have effects of lethargy, somnolence and poor sucking; effect of drug on milk production is unknown; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for drug and any potential adverse effects on breastfed infant from drug or from underlying maternal condition; if exposing a breastfed infant to drug, observe for any potential adverse effectsA: Generally acceptable.

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