In a shelter cat study using 250 mg terbinafine tablets (all doses once daily for 21 days), cats <2.8 kg received 1/4 of a tablet (62.5 mg) per dose, cats 2.8–5.5 kg received 1/2 of a tablet (125 mg) per dose, and cats >5.5 kg received 1 tablet (250 mg) per dose (Moriello et al.
Fill the syringe by pulling the plunger until it reaches the graduation corresponding to the correct mL dose as indicated at the top of the syringe ring (Figure 3). The mode of action of itraconazole is based on its highly selective binding ability to fungal cytochrome p-450 iso-enzymes. Cats in animal shelters and catteries are much more likely to harbor ringworm than pet cats, and isolation of this fungus from even one cat or kitten in a cattery warrants treatment of the entire cattery.
In a shelter cat study using 250 mg terbinafine tablets (all doses once daily for 21 days), cats <2.8 kg received 1/4 of a tablet (62.5 mg) per dose, cats 2.8–5.5 kg received 1/2 of a tablet (125 mg) per dose, and cats >5.5 kg received 1 tablet (250 mg) per dose (Moriello et al. The U.S. Food and Drug Administration (FDA) recently approved ITRAFUNGOL, an itraconazole oral solution for treating dermatophytosis caused by Manufactured for Elanco US Inc., ITRAFUNGOL is a prescription animal drug and comes with a graduated dosing oral syringe. 2004 Apr;15(2):99-107. doi: 10.1111/j.1365-3164.2004.00361.x.Puls C, Johnson A, Young K, Hare J, Rosenkrans K, Young L, Moriello K.J Feline Med Surg.
This inhibits the synthesis of ergosterol and affects membrane-bound enzyme function and membrane permeability. ITRAFUNGOL has not been shown to be sporicidal; therefore in order to reduce zoonotic potential, environmental contamination, and to decrease course of the disease, topical and environmental treatment should also be utilized.
Select one or more newsletters to continue. Hypersalivation was the most frequent abnormal clinical observation related to treatment with ITRAFUNGOL and the incidence increased with the higher doses.
Detailed Itraconazole dosage information for adults and children. In this study, 514 cats diagnosed with dermatophytosis were randomly administered itraconazole oral solution or an active control. There were no corresponding adverse clinical effects noted on observation or on clinical pathology analysis.
These histopathology findings are likely related to exposure to ITRAFUNGOL, specifically the vehicle component hydroxypropyl-β-cyclodextrin (HPβCD).
Cats received a daily dose of either itraconazole oral solution for three alternating weeks plus a placebo tablet once daily for 5 consecutive weeks, or a placebo solution for three alternating weeks plus the active control once daily for five weeks. The daily dosage is 5 mg/kg (0.5 mL/kg) body weight administered once daily on alternating weeks for 3 treatment cycles.
Food consumption was consistently higher throughout the study in the control group than the ITRAFUNGOL group. Mild gingival bleeding and perioral irritation (patchy alopecia and erythema) was noted in cats in the 3X and 5X groups. Itraconazole for cats dosage or Itrafungol for cats dosing will depend on the severity of the sporotrichosis.
In the lungs, one 3X group cat and five 5X cats had intra-alveolar foamy macrophages; five 5X group cats had intra-alveolar syncytial cells.These histopathology findings are likely related to exposure to ITRAFUNGOL, specifically the vehicle component hydroxypropyl-β-cyclodextrin (HPβCD).
The labeling for ITRAFUNGOL is written specifically for cats and includes all necessary information, including associated risks, so you can use the drug safely and effectively in cats. Based on our recommended protocol, brand name itraconazole should be used at 5 - 10mg/kg orally once daily for 21 days IN ADDITION to twice weekly lime sulfur dips (at 8oz/gallon).
Wash hands and exposed skin after use.
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