2017 Feb 10;2016:779-788. eCollection 2016.Tam TS, Wu MH, Masson SC, Tsang MP, Stabler SN, Kinkade A, Tung A, Tejani AM.Cochrane Database Syst Rev. This site needs JavaScript to work properly.
They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney). doi: 10.1002/14651858.CD008167.pub2.Br J Clin Pharmacol. doi: 10.21037/atm.2016.10.42.Rosa J, Zelinka T, Petrák O, Štrauch B, Holaj R, Widimský J Jr.Curr Hypertens Rep. 2016 Nov;18(11):81. doi: 10.1007/s11906-016-0690-1. Please enable it to take advantage of the complete set of features!
We comply with the HONcode standard for trustworthy health information - Dose equivalencies were eplerenone-spironolactone 4.5-to-1 (e.g., eplerenone 125∼spironolactone 25), amiloride-spironolactone 3.3-to-1, and eplerenone-amiloride 1.4-to-1. Loop diuretic conversion - Equivalent Doses Furosemide (Lasix) 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide (Bumex) 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretic #Equivalent #Doses #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology Made Ridiculously Simple - … Thiazide (/ ˈ θ aɪ ə z aɪ d /) refers to both a class of sulfur-containing organic molecules and a class of diuretics based on the chemical structure of benzothiadiazine. Increases in serum potassium from amiloride and spironolactone at commonly used doses averaged 0.14-0.29 mEq/l; the dose doubling effect was 0.16 (0.10, 0.22). 2016 Oct;4(Suppl 1):S11. 2010 Jan 20;(1):CD008167. The thiazide drug class was discovered and developed at Merck and Co. in the 1950s. Thiazides decrease sodium reabsorption which increases fluid loss in urine, which in turn decreases extracellular fluid and plasma volume. They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney). Thiazides also work in other ways to lower blood pressure. One approach to overcome loop diuretic resistance is the addition of a thiazide-type diuretic to produce diuretic synergy via “sequential nephron blockade,” first described more than 40 years ago. Further, the decreased peripheral vascular resistance is accomplished through TZD activation of an extrarenal target, resulting in inhibition of vascular constriction. The first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. Thiazide diuretics are a type of diuretic (a drug that increases urine flow). An important and challenging subset of heart failure patients exhibit fluid overload despite significant doses of loop diuretics.
Thiazide diuretics can lower potassium and magnesium blood levels since they are both eliminated in urine. Wolters Kluwer This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.
2017 Feb 28;2(2):CD008996. Unable to load your delegates due to an error
doi: 10.1002/14651858.CD008996.pub2.Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A.Ann Transl Med. Thiazide diuretics are a type of diuretic (a drug that increases urine flow). Wolters Kluwer
doi: 10.1002/14651858.CD008167.pub3.J Gen Intern Med. If blood pressure control worsens or if volume expansion occurs as CKD progresses from Stages 1-3 to Stages 4-5 during treatment with a thiazide diuretic (either as monotherapy or as fixed-dose combination antihypertensive therapy), a loop diuretic should be substituted for the thiazide diuretic. Name must be less than 100 characters 2017 Aug;32(8):860-862. doi: 10.1007/s11606-017-4060-8.AMIA Annu Symp Proc.
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