The basis of loading dose calculations involves a drug's volume of distribution (Vd). If you are a human and are seeing this field, please leave it blank.

Administration of phenytoin via enteral feeding tubes is not recommended due to variable absorption of phenytoin. The original Winter-Tozer equations for these two patient populations have consistently been shown to be inaccurate, although one may still find the original equations in textbooks or other resources.1,2,5

Kane SP.

Phenytoin sodium 'top-up' dose (mg) = (20 - measured concentration (mg/L)) x 0.7 x wt (kg) Table 2 gives the approximate increase in concentration following doses of 250–750mg.

Conversion half-life to phenytoin ~15 minutes : SE: Hypotension, arrhythmias .

All rights reserved. Dilute in NS ONLY, final concentration 2-10 mg/mL divided doses. Because phenytoin has demonstrated some saturable and erratic oral absorption beyond 400 mg, the use of large oral loading doses is controversial. 7 x wt (kg) Table 2 gives the approximate increase in concentration following doses of 250 to 750mg.

When should the maintenance dose begin? Resolved comments If the phenytoin concentration is >12 mg/mL, the dose may be increased by 30 mg/day. Two studies have examined the safety and efficacy of phenytoin oral loading doses. If the phenytoin concentration is >16 ug/mL, any change may result in a significant increase in … For phenytoin, a Δ C p = D o s e ∗ S V d. For phenytoin, a Vd of 0.7 L/kg is used. Page Information For example, if the patient weighs 70kg and has a measured concentration of 5mg/L, a single dose of 750mg will increase the concentration to around 20mg/L (5mg/L + 15mg/L). For example, if the patient weighs 70kg and has a measured concentration of 5mg/L, a single dose of 750mg will increase the concentration to around 20mg/L (5mg/L + 15mg/L).


Phenytoin Dosing Calculator. Phenytoin oral loading doses may be advantageous in stable patients with subtherapeutic phenytoin concentrations, particularly in those presenting to the emergency department without IV access. Critical Care and Hospital Pharmacy Resources for Hospital Pharmacists, PGY-1 Pharmacy Residents, PharmD students, and PreceptorsFor estimating the effective phenytoin level in the context of a low serum albuminCorrected Phenytoin = Total Phenytoin Level / ( (0.2 x albumin) + 0.1)If clcr < 20 mL/min then Corrected Phenytoin = Total Phenytoin Level / ( (0.1 x albumin) + 0.1) Success! The most commonly cited trial

In patients with low serum albumin concentrations, a higher proportion of the total (measured) phenytoin concentration is unbound and caution is therefore required when interpreting the result.The equation below gives an albumin corrected, total phenytoin concentration which can be compared with the target concentration range (10 to 20mg/L).  

The following equation is a simple pharmacokinetic equation to estimate a loading dose or resulting serum concentration of a drug. This is an unprecedented time.
Order phenytoin 100mg IV TID . The basis of loading dose calculations involves a drug's volume of distribution (Vd). Export to Word \\ Corrected\;phenytoin\;(equation\;1) = \frac{(Measured\;phenytoin)}{0.25 * Albumin + 0.1} Loading... In patients with hypoalbuminemia, a corrected equation must be used to account for reduced phenytoin protein binding. 1- Empiric dosing method 2. If the phenytoin concentration is 7-12 ug/mL, the dose may be increased by 50 mg/day. If the phenytoin concentration is 7-12 mcg/mL, the dose may be increased by 50 mg/day. Press 'Calculate' to view calculation results.

In patients with hypoalbuminemia, a corrected equation must be used to account for reduced phenytoin protein binding. PHENYTOIN (Dilantin) infusion.

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