sertraline oral and clomipramine oral both increase serotonin levels. doses, both clomipramine and sertraline showed a similar the-rapeutic efficacy in the treatment of OCD. Drug interactions are reported only by a few people who take Sertraline hydrochloride and Clomipramine hydrochloride together.
Please check with a physician if you have health questions or concerns. Treatment effects persisted through 5 to 22 months of follow-up from onset of combination therapy. The study is created by eHealthMe based on reports of 5 people who take the same drugs from the FDA, and is updated regularly. Two patients had prolongation of QTc intervals and 2 developed tachycardia while taking CMI and SSRI combinations. The information provided here is for informational purposes only. J Clin Psychopharmacol 1994 Apr;14(2):90-8. Too much serotonin is a potentially life-threatening situation. Sertraline is a weak inhibitor of CYP2D6, which metabolizes clomipramine. Drug interactions with sertraline oral and clomipramine oral. Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed. ... Never use this combination of drugs because of high risk for dangerous interaction. Combination treatment with clomipramine and selective serotonin reuptake inhibitors for obsessive-compulsive disorder in children and adolescents. Please enable it to take advantage of the complete set of features!
The results indicate that sertraline is as effective as clomipramine in the treatment of OCD and is better tolerated. Sertraline dose-dependently slows the metabolism of clomipramine via CYP2D6. This open-label case series presents 7 patients (6 male, 1 female) ages 9 to 23 years with OCD who were effectively treated with combination of CMI plus an SSRI. Clipboard, Search History, and several other advanced features are temporarily unavailable. doi: 10.4088/JCP.13f08883.Mataix-Cols D, Rauch SL, Manzo PA, Jenike MA, Baer L.Am J Psychiatry.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Recommendations are made to monitor electrocardiograms, CMI blood concentrations, and vital signs in all cases because SSRIs can increase the blood levels of CMI and/or its active metabolite, desmethylclomipramine (DCMI). Unable to load your delegates due to an error Author information: (1)Department of Psychiatry, University of … Frequently, OCD patients receiving monotherapy experience low treatment response rates and problematic side effects that may result in discontinuation or noncompliance. Atypon 18.Preskorn SH, Alderman J, Chung M, Harrison W, Messig M, Harris S. Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Figueroa Y(1), Rosenberg DR, Birmaher B, Keshavan MS. This tool may not cover all possible drug interactions. It is used for the treatment of obsessive–compulsive disorder, panic disorder, major depressive disorder, and chronic pain. Name must be less than 100 characters sertraline oral and clomipramine oral both increase affecting serotonin levels in the blood. Unable to load your collection due to an error Clomipramine oral capsule is a prescription medication used to treat the excessive and repetitive ideas, thoughts, and impulses of obsessive-compulsive disorder. 2003;5(9):583-95. doi: 10.2165/00148581-200305090-00002. This site needs JavaScript to work properly.
Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. 2013 Dec;74(12):e1128-33. 2014 Nov;20(6):438-47. doi: 10.1097/01.pra.0000456592.20622.45.Lewin AB, Storch EA, Geffken GR, Goodman WK, Murphy TK.Scahill L, Erenberg G, Berlin CM Jr, Budman C, Coffey BJ, Jankovic J, Kiessling L, King RA, Kurlan R, Lang A, Mink J, Murphy T, Zinner S, Walkup J; Tourette Syndrome Association Medical Advisory Board: Practice Committee.NeuroRx. Psychiatr Serv. 2006 Apr;3(2):192-206. doi: 10.1016/j.nurx.2006.01.009.Paediatr Drugs. You may want to consider another combination. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. …
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