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Data collection, management, and analysis were performed at the network’s data coordinating center at Duke Clinical Research Institute. ACE denotes angiotensin-converting enzyme, ARB angiotensin-receptor blocker, ECG electrocardiography, and NT-proBNP N-terminal pro–brain natriuretic peptide.
(Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, Approximately half of patients with heart failure have a preserved ejection fraction.In assessing activity tolerance, intermittent supervised exercise tests may not reflect the full effect of a therapy on a patient’s daily functional status. The headaches are horrendous, body aches, back pain, dizziness, extreme exhaustion, mental confusion. Epub 2015 Nov 26.Semergen. Average Daily Arbitrary Accelerometer Units, According to Subgroup The full entry criteria are provided in Tables S1 and S2 in the The design of the trial, which was a multicenter, randomized, double-blind, placebo-controlled, crossover study, has been described previously.Patients were supplied with a belt outfitted with two kinetic activity monitors (Kersh Health) containing high-sensitivity, triaxis accelerometers (KXUD9-2050, Kionix) (Fig. Wiley S2 in the Shown are the absolute values and differences between the two treatments (isosorbide mononitrate minus placebo) for the average daily arbitrary accelerometer units (Panel A) and hours of activity per day (Panel B) during the 120-mg phase and for daily arbitrary accelerometer units for all three doses (30 mg, 60 mg, and 120 mg) combined (Panel C). Atypon The I bars indicate 95% confidence intervals.Shown are the average daily arbitrary accelerometer units in each of the prespecified subgroups and the between-group treatment differences and 95% confidence intervals. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Since only four patients were treated with hydralazine, the subgroup analysis for this variable alone is not shown. Scintigraphic counts were corrected for decay and expressed as a percentage of the whole. After the second period, patients returned to repeat end-point assessments and to return the accelerometers and any unused tablets of isosorbide mononitrate or placebo provided during the second period.The prespecified primary end point was a comparison of average daily accelerometer units during the period in which patients were receiving the 120-mg dose of isosorbide mononitrate as compared with placebo. When I stopped taking the medication all the symptoms eventually left including my chest pains. S2 in the During the 120-mg phase, 101 patients during the first period and 91 during the second period had usable accelerometer data, with a median of 16 complete days of accelerometer data (interquartile range, 12 to 20) during the first period and 14 complete days (interquartile range, 10 to 18) during the second period (P<0.001) (Fig. According to the crossover design, the same patients were compared during the two treatment periods.
In addition, two other accelerometer-derived activity end points were prespecified. The term “nitrate tolerance” refers to the decreasing effect of nitrates in patients after long-term exposure to this drug class. Activity levels decreased progressively and significantly with increased doses of isosorbide mononitrate (but not placebo). Please enable it to take advantage of the complete set of features! Sep 8, 2020
Epub 2020 Jul 29.Braz J Med Biol Res. Unable to load your delegates due to an error We also speculate that inorganic nitrite or nitrateIn conclusion, in patients with heart failure with a preserved ejection fraction, the receipt of isosorbide mononitrate, as compared with placebo, decreased daily activity levels.
Secondary end points included hours of activity per day during the 120-mg phase, daily accelerometer units during all three dose regimens, quality-of-life scores, 6-minute walk distance, and levels of N-terminal pro–brain natriuretic peptide (NT-proBNP).In the group receiving the 120-mg dose of isosorbide mononitrate, as compared with the placebo group, there was a nonsignificant trend toward lower daily activity (−381 accelerometer units; 95% confidence interval [CI], −780 to 17; P=0.06) and a significant decrease in hours of activity per day (−0.30 hours; 95% CI, −0.55 to −0.05; P=0.02).
Inhibitors of nitrate tolerance include renin–angiotensin–aldosterone antagonists, carvedilol, statins, and hydralazine.
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