Latuda epocrates diamox


Pre-existing hypokalemia and hyperuricemia can also be potentiated by carbonic anhydrase inhibitors. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.While you are taking Latuda, you may be more sensitive to temperature extremes such as very hot or cold conditions. Initial dose titration is not required; shown to be effective in a dose range of 40-160 mg/dayEffectiveness for longer-term use (ie, >6 weeks) has not been established in controlled studies; therefore, the physician who elects to use lurasidone for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patientIndicated for treatment of schizophrenia in adolescents aged 13-17 yearsIndicated as monotherapy for major depressive episode associated with bipolar I disorder (bipolar depression) in adolescents aged 10-17 yr20 mg PO qDay; initial dose titration is not requiredMay increase dose after 1 week based on clinical response; not to exceed 80 mg qDay Effective dose range is 20-80 mg/dayClinical studies found most patients (67%) received 20-40 mg/dayEffectiveness for longer-term use (ie, >6 weeks) has not been established in controlled studies; therefore, the physician who elects to use lurasidone for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patientHypersensitivity (urticaria, throat swelling, tongue swelling, and dyspnea)Coadministration with strong CYP3A4 inhibitors (eg, ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil)Coadministration with strong CYP3A4 inducers (eg, rifampin, St. John’s wort, phenytoin, carbamazepine)Possibility of suicide attempt inherent to psychotic illness; close supervision required when therapy is initiated, dosage is changed, or drug is discontinued; the risk of suicidal thoughts and behaviors in pediatric and young adult patients extends to longer-term use (eg, >4 months) is unknown; there is substantial evidence from placebo-controlled maintenance studies in adults with MDD that antidepressants delay the recurrence of depressionAntidepressant treatment can increase the risk of developing a manic or hypomanic episode, particularly in patients with bipolar disorderPatients with Parkinson’s disease or dementia with Lewy bodies are reported to have an increased sensitivity to antipsychotic medicationOrthostatic hypotension and syncope reported, possibly due to its alpha-1receptor antagonismRisk of neuroleptic malignant syndrome (NMS) reported in association with administration of antipsychotic drugs, including lurasidone; clinical manifestations of NMS (eg, hyperpyrexia, muscle rigidity, altered mental status, evidence of autonomic instability); additional symptoms (eg, elevated creatine phosphokinase, myoglobinuria [rhabdomyolysis], acute renal failure); the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses or may even arise after discontinuation of treatment; if NMS is suspected, immediately discontinue therapy and provide intensive symptomatic treatment and monitoringHyperprolactinemia reported; galactorrhea, amenorrhea, gynecomastia, and impotence reported with prolactin-elevating compounds; long-standing hyperprolactinemia, when associated with hypogonadism, may lead to decreased bone density in both female and male patientsExercise caution in patients with a history of seizures or with conditions that lower the seizure threshold (eg, Alzheimer’s dementia); conditions that lower the seizure threshold may be more prevalent in patients ≥65 yearsMay cause leukopenia, neutropenia, and agranulocytosis; monitor patients with neutropenia should for fever or other signs of infection and treat promptly if symptoms occur; discontinue treatment in patients with severe neutropenia (ANC <1,000/mm³) and follow WBC until recoveryMay lead to cognitive and motor impairment; caution patients about operating hazardous machineryIncidence of cerebrovascular effects (eg, transient ischemic attacks, stroke) may increaseMay increase QT interval: In trials, increase in baseline adjusted QTc intervals did not exceed mean based on individual correction method (QTcI) was 7.5 ms (120-mg dose) and 4.6 ms (600-mg dose) observed at 2-4 hours after dosing; additionally, in separate trial, QTc did not increase by >60 msec from baseline or exceed 500 msec with supratherapeutic doses (ie, 120 mg/day, 600 mg/day)Acute overdose: If antiarrhythmic therapy is administered, disopyramide, procainamide, and quinidine carry theoretical hazard of additive QT-prolonging effects when given to patient with acute lurasidone overdoseMotor instability, somnolence, and orthostatic hypotension reported, which may lead to falls and, consequently, fractures or other fall-related injuries; assess risk of falls when initiating treatment and recurrently for patients receiving repeated doses, particularly the elderly, with diseases, conditions, or medications that could exacerbate these effectsNeonates exposed to antipsychotic drugs during 3rd trimester of pregnancy are at risk for extrapyramidal symptoms (EPS) and/or withdrawal symptoms after delivery; these complications vary in severity, with some being self-limited and others requiring ICU support and prolonged hospitalizationThere is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to lurasidone during pregnancyNational Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-andresearchprograms/pregnancyregistryConsider development and health benefits of breastfeeding along with mother’s clinical need for drug and any potential adverse effects on breastfed infant from therapy or from underlying maternal conditionA: Generally acceptable.
Meet the experts behind epocrates. Select one or more newsletters to continue. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.Latuda may impair your thinking or reactions. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, any new or unusual muscle movements you cannot control;(in women) irregular menstrual periods, breast or vaginal changes, This is not a complete list of side effects and others may occur. Lithium is also sometimes used to treat depression, schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), disorders of impulse control (inability to resist the urge to perform a harmful action), and certain mental illnesses in children. Subscribe for just $174.99/year or $16.99/month. Stopping suddenly may cause other problems.It is easier to become dangerously overheated and dehydrated while you are taking Latuda. and formulary information changes. Skip the missed dose if it is almost time for your next scheduled dose.

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