The administration of a second dose 60 minutes later to patients not responding well to an initial dose affords little additional benefit. 0000010545 00000 n Within this context, the efficacy and tolerability of sumatriptan tablets is well‐established for the treatment of moderate to severe migraine pain and migraine‐associated symptoms.A retrospective analysis from an open‐label study examined the responsiveness of nonmigraine headaches to sumatriptan, 6‐mg injection, in 43 patients with IHS‐diagnosed migraine of at least moderate pain intensity.Given the frequency of nonmigraine headaches in migraine sufferers and the efficacy of sumatriptan for these headaches in an open‐label study, we conducted a randomized, double‐blind, placebo‐controlled, clinical study to determine the efficacy of sumatriptan, 50‐mg tablets, for the treatment of the spectrum of headaches experienced by patients with disabling IHS‐diagnosed migraine.
We estimated that placebo had an effect on 20% and sumatriptan had 60% effect. reserved for serious infections not responding to other tx: Term. Thus, this study was slightly underpowered. 0000011003 00000 n 0000073541 00000 n
Notably, the response to two 6-mg injections of sumatriptan was not significantly different from that for 6 mg of sumatriptan plus placebo (95 percent confidence interval for the difference, −5 to +17 percent).The patients who had auras before their headache and those who did not responded similarly to sumatriptan.

Because migraine sufferers with disabling headache have the greatest documented need for treatment with 5‐HTThe study was conducted at three centers in the United States between January 1997 and February 1998. 0000005299 00000 n Hougaard A, Tfelt-Hansen P (2015) Review of dose–response curves for acute antimigraine drugs: triptans, 5-HT Durham PL, Russo AF (2002) New insights into the molecular actions of serotonergic antimigraine drugs. 0000011861 00000 n A 24‐hour headache‐free interval was required between treated headaches. 0000004087 00000 n Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Information, resources, and support needed to approach rotations - and life as a resident.Valuable tools for building a rewarding career in health care.Information and tools for librarians about site license offerings.The authorized source of trusted medical research and education for the Chinese-language medical community.The most trusted, influential source of new medical knowledge and clinical best practices in the world.Protocol for Treatment of Patients with Migraine Attacks with Sumatriptan (6 or 8 mg) or PlaceboDemographic and Clinical Characteristics of the Study Population and Details of Migraine Attacks Treated, According to the First Study Injection Given.Proportion of Patients Whose Headache Improved from Severe or Moderate Pain to Mild or No Pain (Open Bars) or to No Pain (Hatched Bars) 30 and 60 Minutes after Treatment with Placebo or 6 or 8 mg of Sumatriptan.Proportion of Patients Whose Headache Improved from Severe or Moderate Pain to Mild or No Pain (Open Bars) or to No Pain (Hatched Bars) 120 Minutes after TreatmentNumber of Patients with a Recurrence of Migraine Attacks within 24 Hours, According to Treatment Group.Most Frequently Reported Adverse Events among Patients with Migraine Attacks Treated with Sumatriptan or Placebo.Protocol for Treatment of Patients with Migraine Attacks with Sumatriptan (6 or 8 mg) or PlaceboDemographic and Clinical Characteristics of the Study Population and Details of Migraine Attacks Treated, According to the First Study Injection Given.Proportion of Patients Whose Headache Improved from Severe or Moderate Pain to Mild or No Pain (Open Bars) or to No Pain (Hatched Bars) 30 and 60 Minutes after Treatment with Placebo or 6 or 8 mg of Sumatriptan.Proportion of Patients Whose Headache Improved from Severe or Moderate Pain to Mild or No Pain (Open Bars) or to No Pain (Hatched Bars) 120 Minutes after TreatmentNumber of Patients with a Recurrence of Migraine Attacks within 24 Hours, According to Treatment Group.Most Frequently Reported Adverse Events among Patients with Migraine Attacks Treated with Sumatriptan or Placebo. I have tried it once in my life and will never even get near it again. Mean age was 34.4 years (range 21–59 years) and mean weight was 69.8 kg (range 47–95 kg). 0000007495 00000 n

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