Special consideration should be given to patients at increased risk of osteoporosis (i.e., post-menopausal women) before initiating corticosteroid therapy.Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not show that they affect the ultimate outcome or natural history of the disease. For chronic overdosage in the face of severe disease requiring continuous steroid therapy, the dosage of prednisolone may be reduced only temporarily, or alternate day treatment may be introduced.The initial dosage of Prednisolone Sodium Phosphate Oral Solution (20 mg prednisolone base per 5 mL) may vary from 1.25 mL to 15 mL (5 to 60 mg prednisolone base) per day depending on the specific disease entity being treated. If you think there has been an overdose, call your poison control center or get medical care right away. In such patients, corticosteroid-induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia.Corticosteroids should not be used in cerebral malaria.The use of prednisolone in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen.If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. Corticosteroids may also mask some signs of infection after it has already started.Chicken pox and measles, for example, can have a more serious or even fatal course in non-immune children or adults on corticosteroids. Killed or inactivated vaccines may be administered, however, the response to such vaccines cannot be predicted. Select one or more newsletters to continue.
Prednisolone is rapidly and well absorbed from the gastrointestinal tract following oral administration. Read all information given to you. If after long term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.In the treatment of acute exacerbations of multiple sclerosis, daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day or 4 to 8 mg dexamethasone every other day for one month have been shown to be effective.In pediatric patients, the initial dose of Prednisolone Sodium Phosphate Oral Solution (20 mg prednisolone base per 5 mL) may vary depending on the specific disease entity being treated. Prednisolone doses of 7.5 mg/day or higher have been associated with an increased relative risk of both vertebral and nonvertebral fractures, even in the presence of higher bone density compared to patients with involutional osteoporosis.Routine screening of geriatric patients, including regular assessments of bone mineral density and institution of fracture prevention strategies along with regular review of prednisolone sodium phosphate indication should be undertaken to minimize complications and keep the dose at the lowest acceptable level. You may report side effects to the FDA at 1-800-332-1088. Losses of bone mineral density appear to be greatest early on in the course of treatment and may recover over time after steroid withdrawal or use of lower doses (i.e., ≤5 mg/day). Follow all instructions closely. This is not a list of all drugs or health problems that interact with this medicine (prednisolone tablets). Read all information given to you. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy.Due to inhibition of antibody response, patients on prolonged corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines. Plasma prednisolone concentrations were higher in elderly subjects, and the higher AUCs of total and unbound prednisolone were most likely reflective of an impaired metabolic clearance, evidenced by reduced fractional urinary clearance of 6β-hydroxyprednisolone. You may also report side effects at https://www.fda.gov/medwatch.
The use of oral corticosteroids is not recommended in the treatment of optic neuritis and may lead to an increase in the risk of new episodes. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids.Intraocular pressure may become elevated in some individuals.
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