Timolol Maleate Ophthalmic Gel Forming Solution, 0.25% timolol equivalent, is supplied in a white low density polyethylene (LDPE) dispenser with a controlled drop tip and a yellow polypropylene cap as follows: Alopecia, psoriasiform rash, exacerbation of psoriasis, and systemic lupus erythematosus also have been reported.Diarrhea, nausea, dyspepsia, anorexia, and dry mouth have been reported in patients receiving topical timolol therapy.Retroperitoneal fibrosis, impotence, decreased libido, and Peyronie's disease have been reported in some patients receiving topical timolol therapy.Because β-adrenergic blocking agents may mask the signs and symptoms of acute hypoglycemia, these agents should be administered with caution in patients subject to spontaneous hypoglycemia and in diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. The drug should be used with caution in patients with diminished pulmonary function, and is contraindicated in patients with asthma or a history of asthma and in patients with severe chronic obstructive pulmonary disease. Store at 15-25°C (59-77°F). Ophthalmology. Rarely, death associated with cardiac failure has been reported in patients receiving systemic or topical (ocular) timolol.Headache and dizziness occurred in 1-5% of patients receiving timolol maleate gel-forming ophthalmic solution in clinical studies. IOVS. Timolol ophthalmic solution is contraindicated in patients with bronchial asthma or a history of bronchial asthma and in patients with severe chronic obstructive pulmonary disease, sinus bradycardia, atrioventricular block greater than first degree, overt cardiac failure, or cardiogenic shock. There are no adequate and controlled studies to date using timolol ophthalmic solution in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.Reproduction studies in male and female rats using oral timolol dosages up to 125 times the maximum human oral dosage (based on patient weight of 50 kg) have not revealed evidence of impaired fertility.Timolol is distributed into milk following oral or ophthalmic administration.
Following topical administration of timolol 0.5% solution twice daily to the eye in a limited number of individuals, mean peak plasma concentrations were 0.46 or 0.35 ng/mL following the morning or afternoon dose, respectively. Topical timolol also has been used to reduce elevated IOP in patients with aphakic glaucoma and some secondary glaucomas. Slight reduction of resting heart rate also may occur, and slightly decreased blood pressure has been reported in some patients receiving high doses of the drug (i.e., 1 drop of a 1% solution to each eye). It is available in multiple generic and brand versions. Increased fetal resorptions were also observed in rabbits receiving oral timolol dosages 14,000 times the systemic exposure following the maximum recommended human ophthalmic dosage. Timolol ophthalmic solutions usually should not be used concomitantly with another ophthalmic β-adrenergic blocking agent concomitantly; in patients being transferred from another β-blocker to timolol, the other β-blocker should be discontinued before initiating timolol.Patients with mild or moderately severe chronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema), bronchospastic disease, or a history of bronchospastic disease (other than bronchial asthma or a history of bronchial asthma in which condition timolol ophthalmic solution is contraindicated) generally should not receive β-adrenergic blocking agents. Eligibility requirements vary for each program.There are currently no Patient Assistance Programs that we know about for this drug.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This timolol ophthalmic price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. Check with your FSA Administrator about reimbursement procedures for your plan.The FSA Debit Card would not be charged if something is not considered FSA eligible under your plan. When used in conjunction with these agents, timolol may have an additive IOP-lowering effect. Apply other eye medications at least 10 minutes before timolol gel solution. Flexible Spending Accounts will reimburse you for incurred expenses during your FSA plan year (period of coverage). Efficacy and Safety of Timolol Solution Once Daily vs Timolol Gel … Because of the potential for serious adverse reactions from timolol in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.When used in conjunction with topical miotics, latanoprost, and/or topical or systemically administered carbonic anhydrase inhibitors, the effect of timolol in lowering IOP may be additive. Some FSA Administrators could still require a receipt to substantiate a claim. If further reduction in IOP is needed in patients receiving 1 drop of a timolol 0.5% gel-forming solution once daily, concomitant therapy should be considered. Dosages exceeding 1 drop of a 0.5% solution twice daily generally have not produced a further reduction in IOP.

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