The concentrate must be mixed with a liquid (diluent) before using it. Administer by nebulization using with a standard jet nebulizer (with a face mask or mouthpiece) connected to an air compressor. If patients find that treatment with XOPENEX Inhalation Solution becomes less effective for symptomatic relief, symptoms become worse, or they need to use the product more frequently than usual, they should seek medical attention immediately.Inform patients that XOPENEX Inhalation Solution can produce paradoxical bronchospasm. The decrease is usually transient, not requiring supplementation.The following serious adverse reactions are described below and elsewhere in the labeling:Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of the drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.Adverse reaction information concerning XOPENEX Inhalation Solution in adults and adolescents is derived from one 4-week, multicenter, randomized, double-blind, active-, and placebo-controlled trial in 362 patients with asthma 12 years of age and older. You may report side effects to FDA at 1-800-FDA-1088.Tell your doctor if you have used an MAO inhibitor in the past 14 days.
To enroll in the Asthma & Pregnancy Study or for more information about the registry, call 1-877-311-8972 or visit www.mothertobaby.org/ongoing-study/asthma [see Advise patients to dilute Xopenex Inhalation Solution Concentrate with sterile normal saline before administration by nebulization.Advise patients how to store Xopenex Inhalation Solution Concentrate. Use all medications as directed by your doctor. We comply with the HONcode standard for trustworthy health information - Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Clinically significant changes in systolic and diastolic blood pressure have been seen in individual patients and could be expected to occur in some patients after the use of any beta-adrenergic bronchodilator.Changes in blood glucose may occur. These events have been chosen for inclusion due to their seriousness, their frequency of reporting, or their likely beta-mediated mechanism: angioedema, anaphylaxis, arrhythmias (including atrial fibrillation, supraventricular tachycardia, extrasystoles), asthma, chest pain, cough increased, dysphonia, dyspnea, gastroesophageal reflux disease (GERD), metabolic acidosis, nausea, nervousness, rash, tachycardia, tremor, urticaria.In addition, XOPENEX Inhalation Solution, like other sympathomimetic agents, can cause adverse reactions such as hypertension, angina, vertigo, central nervous system stimulation, sleeplessness, headache, and drying or irritation of the oropharynx.Avoid concomitant use of other short-acting sympathomimetic bronchodilators or epinephrine in patients being treated with XOPENEX Inhalation Solution. At 180 minutes after administration, the bronchoprotective effect of 1.25 mg of XOPENEX was comparable to that of 2.5 mg of racemic albuterol sulfate. It should be recognized that paradoxical bronchospasm, when associated with inhaled formulations, frequently occurs with the first use of a new vial.Asthma may deteriorate acutely over a period of hours or chronically over several days or longer. In addition, beta-agonists have been reported to produce electrocardiogram (ECG) changes, such as flattening of the t-wave, prolongation of the QTc interval, and ST segment depression. Version: 8.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Dilute with sterile normal saline before use.Who should not use Xopenex Inhalation Solution Concentrate?Do not use Xopenex Inhalation Solution Concentrate if youWhat should I tell my doctor before using Xopenex Inhalation Solution Concentrate?Before you use Xopenex Inhalation Solution Concentrate, tell your doctor if you have:How should I use Xopenex Inhalation Solution Concentrate?You will need to mix your Xopenex Inhalation Solution Concentrate with sterile normal saline before you give your dose.Do not use your Xopenex Inhalation Solution Concentrate more often than your doctor tells you to.Get medical help right away if Xopenex Inhalation Solution Concentrate:Only use Xopenex Inhalation Solution Concentrate if it is colorless.What are the possible side effects of Xopenex Inhalation Solution Concentrate?Xopenex Inhalation Solution Concentrate can cause serious side effects including:The most common side effects of Xopenex Inhalation Solution Concentrate include:How should I store Xopenex Inhalation Solution Concentrate?Keep Xopenex Inhalation Solution Concentrate and all medicines out of the reach of children.General information about the safe and effective use of Xopenex Inhalation Solution Concentrate.What are the ingredients in Xopenex Inhalation Solution Concentrate?Instructions for Using Xopenex Inhalation Solution ConcentrateYou will need to mix your Xopenex Inhalation Solution Concentrate with sterile normal saline before you give your dose.We comply with the HONcode standard for trustworthy health information -
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