301-223-2300 Please try after some time.Get new journal Tables of Contents sent right to your email inbox By continuing to use this website you are giving consent to cookies being used. However, acyclovir has been reported to cause neurotoxicity in patients with acute or chronic kidney disease.This case presents an occurrence of acyclovir-induced toxic encephalopathy in a patient with normal renal function. These include cidofovir, adefovir dipivoxil, and tenofovir, as well as acyclovir.
disease, acyclovir has been associated with renal and central nervous system toxicity in both therapeutic use and overdose. Haefeli W, Schoenenberger R, Weiss P, Ritz R. Acyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdose. [7]. Acyclovir levels in kidneytissue can reach IO times those in serum and may account for the propensity of this drug to cause renal toxicity [ 121.
[6]. Your Email: Adequate saline hydration is important when administrating intravenous acyclovir. Avoiding acyclovir neurotoxicity in patients with chronic renal failure undergoing haemodialysis. A single haemodialysis session decreases the CMMG and acyclovir concentrations at least 50-60% (Figure 4) and often gives a dramatic clinical improvement [15]. Tiredness, confusion and visual and auditory hallucinations were the most common symptoms reported among 37 patients, encephalitis patients excluded (table 1).
Braun J, Apel I, Schaffer S, Schumacher M, Berger M. Delirium during oral therapy of herpes zoster with acyclovir. One main finding is that the majority of affected patients have had renal insufficiency. Acyclovir-induced neuropsychiatric symptoms in ESRD patients may develop within a few hours after the first dose [9]. Renal biopsy was performed in order to confirm the diagnosis. This website uses cookies. Message: Feldman S, Rodman J, Gregory B. [2]. [14]. Dosage and type of neuropsychiatric symptoms was also investigated. Wolters Kluwer Health Perazella M. Crystal-induced acute renal failure. Intravenous acyclovir, 300 mg once daily, was instituted according to renal function and weight (the patient was on continuous replacement therapy: "PRISMA"). Case report and brief review of central nervous system side-effects of acyclovir. Intravenous acyclovir is excreted in the urine 60- 90 % unchanged and 1-10 % as CMMG in a patient without renal failure. A 63-year-old male presented to the emergency department with ataxia, tremors, fluctuating aphasia, confusion, agitation, and fatigue. Message: Your Name: (optional) Day 2 she became depressed and irritated and her condition deteriorated. Death. Please try after some time.Your message has been successfully sent to your colleague.Some error has occurred while processing your request. This page includes the following topics and synonyms: Drug Dosing in Chronic Kidney Disease, Medication Dosing in Chronic Kidney Disease, Renal Dosing, Antibiotic Dose Adjustments in Impaired Renal Function, Antihypertensive Dose Adjustments in Impaired Renal Function, Analgesic Dose Adjustments in Impaired Renal Function, ACE Inhibitor and Angiotensin Receptor Blocker Adjustments … The case described in this vignette is an example of the clinical manifestation of acyclovir crystal obstructive nephrotoxicity.
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