Abbate, F. et al.
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1Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. The intracellular distribution of carbonic anhydrase was studied in nine human donor kidneys by the histochemi-cal method of Hansson and by an immunofluorescence technique using antisera specific against the cytoplasmic isoenzymes HCA B and HCA C. Only HCA C was found in the renal tubules. 406, No. S. Karger AG, Basel, Switzerland Cloning, characterization and inhibition studies of the cytosolic isozyme III with sulfonamides. 51 February 2014 | Journal of Applied Physiology, Vol. 1Respiratory Physiology & Neurobiology, Vol. 1. 86, No. Supuran, C. T. & Clare, B. W. Carbonic anhydrase activators. 9Insect Biochemistry and Molecular Biology, Vol. Epub 2012 May 23. 1Biochimica et Biophysica Acta (BBA) - Enzymology, Vol.
Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Copyright © 1967 the American Physiological Society 4Protein Expression and Purification, Vol. Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked Dubois, L. et al. 73, No. THE ROLE OF CARBONIC ANHYDRASE IN RENAL REABSORPTION OF BICARBONATE BYT. Krungkrai, J. et al. Carbonic anhydrase inhibitors: X ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Carbonic anhydrase inhibitors: X ray crystallographic structure of the adduct of human isozyme II with a EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. 193, No. Applied Radiation and Isotopes, Vol. General Topics, Vol. 116, No. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Clipboard, Search History, and several other advanced features are temporarily unavailable. In the meantime, to ensure continued support, we are displaying the site without styles 14, No. Furthermore, recent studies suggest that CA activation may provide a novel therapy for Alzheimer's disease. Vullo, D. et al. 57, No. 301, No. 95, No. 4Journal of the Neurological Sciences, Vol. 2Journal of Neurosurgical Anesthesiology, Vol. 75, No.
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Part 74. It is irritant to the corneal and conjunctival surface and systemic absorption may rarely give rise to sulphonamide-like side-effects. CAIs include the classical inhibitors acetazolamide (compound 1), ... diuretic inhibits the kidney's ability to reabsorb sodium in the ascending loop.
14, No.
Hon, W. C. et al. 816, No. 416 July 2007 | Phosphorus, Sulfur, and Silicon and the Related Elements, Vol. 4Journal of Ocular Pharmacology and Therapeutics, Vol. Carbonic anhydrase inhibitors suppress the activity of these enzymes, preventing reabsorption of bicarbonate ion in the proximal tubule, which leads to several effects, including bicarbonate and potassium retention in the urine and decreased sodium absorption, acting, in general, as mild diuretics. Casini, A. et al. 55, No. Carbonic anhydrase inhibitors reduce the activity of carbonic anhydrase, an enzyme responsible for catalyzing the reaction between carbon dioxide and water into carbonic acid and then bicarbonate. Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. Activation of isoforms I, II, IV, VA, VII and XIV with Sun, M.-K. & Alkon, D. L. Carbonic anhydrase gating of attention: memory therapy and enhancement. Carbonic anhydrase inhibitors. 4Atmospheric Environment. Vullo, D. et al. Abbate, F. et al. Potter, C. P. & Harris, A. L. Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Scozzafava, A. 1Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 3120 August 2018 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. & Supuran, C. T. Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold. Part A. 537, No. 3Environmental Pollution Series B, Chemical and Physical, Vol. Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. 93, No. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. This reduces the resorption of bicarbonate from the proximal tubule in the kidneys, which causes a direct increase in bicarbonate excretion and mild increases in sodium, and potassium excretion. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. 248, No. Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates. 11 June 1979 | American Journal of Physiology-Endocrinology and Metabolism, Vol. Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in titration calorimetry (ITC). 72, No.
Left panel: Individual experiments. 86, No. Carbonic anhydrase inhibitors. 769, No. 431 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol.
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