Dorzolamide is a sulfonamide and inhibits carbonic anhydrase in the eye, thus reducing the rate of aqueous humor formation with subsequent lowering of IOP. This dose represents an estimated plasma C The increased incidence of urinary bladder papillomas seen in the high-dose male rats is a class- effect of carbonic anhydrase inhibitors in rats.
Contact lenses should be removed prior to administration of the solution. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Following topical ocular administration, Dorzolamide hydrochloride ophthalmic solution reduces elevated intraocular pressure. or inflammation; recent ocular surgery; moderate-to-severe renal or hepatic insufficiency; angle-closure glaucoma; concomitant
There is an increased potential for developing corneal ede ma in patients with low endothelial cell counts. The metabolite has less affinity for CA-II and is less selective than dorzolamide, but also binds to CA-I. A slight delay in postnatal development (incisor eruption, vaginal canalization and eye openings), secondary to lower fetal body weight, was noted. Each mL of Dorzolamide hydrochloride ophthalmic solution 2% contains 20 mg Dorzolamide (22.3 mg of Dorzolamide hydrochloride USP).
The concomitant administration of Dorzolamide hydrochloride ophthalmic solution and oral carbonic anhydrase inhibitors is not re commended.Although aci d-base and electrolyte disturbances were not reported in the clinical trials with Dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inh ibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy).
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure: signs and symptoms of systemic allergic reactions including angioedema, bronchospasm, pruritus, and urticaria; Stevens-Johnson syndrome and toxic epidermal necrolysis; dizziness, paresthesia; ocular pain, transient myopia, choroidal detachment following filtration surgery, eyelid crusting; dyspnea; contact dermatitis, epistaxis, dry mouth and throat irritation.There is a potential for an additive effect on the known s ystemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and Dorzolamide hydrochloride ophthalmic solution. These doses represent estimated plasma Cmax levels in rats, 104 and 52 times higher than the lower limit of detection in human plasma following ocular administration, respectively.The efficacy of Dorzolamide hydrochloride ophthalmic solution was demonstrated in clinical studies in the treatment of elevated intraocular pressure in patients with glaucoma or ocular hypertension (baseline IOP ≥ 23 mmHg).
Inactive ingredients are Mannitol, Hydroxyethyl cellulose, Sodium hydroxide, Tri Sodium citrate dihydrate, and water for injection.
It catalyzes the reversible reaction involving the hydration of carbon di oxide and the dehydration of carbonic acid. Before using the medication for the first time, be sure the tamper evident ring between the bottle and the cap is unbroken (See Figure A).After you have used all of your Dorzolamide hydrochloride ophthalmic solution doses, there will be some Dorzolamide hydrochloride ophthalmic solution medicine left in the dispenser. with subsequent lowering of IOP. Dorzolamide binds moderately to plasma proteins (approximately 33%).Dorzolamide is primarily excreted unchanged in the urine; the metabolite also is excreted in urine.
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