Amantadine Hydrochloride Tablets should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit.When Amantadine Hydrochloride Tablets are added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. However, slowly administered intravenous physostigmine in 1 mg and 2 mg doses in an adult Care should be exercised when administering adrenergic agents, such as isoproterenol, to patients with an amantadine hydrochloride overdose, since the dopaminergic activity of amantadine hydrochloride has been reported to induce malignant arrhythmias.The blood electrolytes, urine pH and urinary output should be monitored. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of amantadine hydrochloride, unless medically indicated. The apparent oral clearance was 0.28 ± 0.11 L/hr/kg (range: 0.14 to 0.62 L/hr/kg). The 100 mg daily dose has not been studied in this pediatric population. Trivalent inactivated influenza vaccine can be administered at any time relative to use of amantadine hydrochloride.Less frequently (1 to 5%) reported adverse reactions are: depression, anxiety and irritability, hallucinations, confusion, anorexia, dry mouth, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, nervousness, dream abnormality, agitation, dry nose, diarrhea and fatigue.Infrequently (0.1 to 1%) occurring adverse reactions are: congestive heart failure, psychosis, urinary retention, dyspnea, skin rash, vomiting, weakness, slurred speech, euphoria, thinking abnormality, amnesia, hyperkinesia, hypertension, decreased libido, and visual disturbance, including punctate subepithelial or other corneal opacity, corneal edema, decreased visual acuity, sensitivity to light, and optic nerve palsy.Rare (less than 0.1%) occurring adverse reactions are: instances of convulsion, leukopenia, neutropenia, eczematoid dermatitis, oculogyric episodes, suicidal attempt, suicide, and suicidal ideation (see WARNINGS).Other adverse reactions reported during postmarketing experience with amantadine hydrochloride usage include:Acute toxicity may be attributable to the anticholinergic effects of amantadine. Protect from light and moisture.Dispense in a tight, light-resistant container as defined in the USP, with child-resistant closure (as required).IDA Pashamylaram, Sangareddy, Telangana 502307, IndiaTrademarks are the property of their respective owners.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Since the excretion rate of amantadine hydrochloride increases rapidly when the urine is acidic, the administration of urine acidifying drugs may increase the elimination of the drug from the body.The following points should be considered before initiating treatment or prophylaxis with Amantadine Hydrochloride Tablets:Deaths due to drug accumulation (overdosage) have been reported in patients with renal impairment, who were prescribed higher than recommended doses of Amantadine Hydrochloride for their level of renal function (see DOSAGE AND ADMINISTRATION; Dosage for Impaired Renal Function and OVERDOSAGE).Patients receiving Amantadine Hydrochloride Tablets who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important.Patients with Parkinson's disease improving on Amantadine Hydrochloride Tablets should resume normal activities gradually and cautiously, consistent with other medical considerations, such as the presence of osteoporosis or phlebothrombosis.Because Amantadine Hydrochloride Tablets have anticholinergic effects and may cause mydriasis, it should not be given to patients with untreated angle closure glaucoma.NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia; neurologic findings including muscle rigidity, involuntary movements, altered consciousness; mental status changes; other disturbances such as autonomic dysfunction, tachycardia, tachypnea, hyper- or hypotension; laboratory findings such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin.The early diagnosis of this condition is important for the appropriate management of these patients.
A decision to use other antiparkinson drugs may be necessary.When Amantadine Hydrochloride Tablets and levodopa are initiated concurrently, the patient can exhibit rapid therapeutic benefits. Occasionally, patients whose responses are not optimal with Amantadine Hydrochloride Tablets at 200mg daily may benefit from an increase up to 400 mg daily in divided doses. Use this medicine (amantadine capsules and tablets) as ordered by your doctor. help if any of these side effects or any other side effects bother you or do not go away: After single dose administration of 25 mg to 75 mg to 7 healthy, elderly male volunteers, the apparent plasma clearance of amantadine was 0.10 ± 0.04 L/hr/kg (range 0.06 to 0.17 L/hr/kg) and the half-life was 29 ± 7 hours (range 20 to 41 hours).
Alternatively, temporary discontinuation of Amantadine Hydrochloride Tablets for several weeks , followed by reinitiation of the drug, may result in regaining benefit in some patients. All drugs may cause side effects. If you think there has been an overdose, call your poison control center or get medical care right away.
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