Patients with additional risk factors for QTc prolongation may be at even higher risk.QT-prolonging Class IA Antiarrhythmics (Highest Risk): May enhance the QTc-prolonging effect of Amiodarone. Patients with other risk factors (eg, older age, female sex, bradycardia, hypokalemia, hypomagnesemia, heart disease, and higher drug concentrations) are likely at greater risk for these toxicities.Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Beta-Blockers: Amiodarone may enhance the bradycardic effect of Beta-Blockers. To gain optimal benefit, avoid the intake of food containing fat between meals, such as biscuits, chocolate and savoury snacks.Orlistat only works in the presence of dietary fat. Consider empiric reduction of 30% to 50% in warfarin dose, though no specific guidelines on dose adjustment have been published.Voriconazole: Amiodarone may enhance the QTc-prolonging effect of Voriconazole. Initiate amiodarone in a clinical setting where continuous ECGs and cardiac resuscitation are available.• Bradycardia/hypotension: May cause hypotension, which may be refractory and fatal, and bradycardia (infusion-rate related).
Patients with additional risk factors for QTc prolongation may be at even higher risk.Sofosbuvir: May enhance the bradycardic effect of Amiodarone.Sparfloxacin: QT-prolonging Agents (Highest Risk) may enhance the QTc-prolonging effect of Sparfloxacin. Discard any unused portions of premixed solutions.Abametapir: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Afatinib: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Afatinib.
Patients with other risk factors (eg, older age, female sex, bradycardia, hypokalemia, hypomagnesemia, heart disease, and higher drug concentrations) are likely at greater risk for these toxicities.Entrectinib: May enhance the QTc-prolonging effect of QT-prolonging Agents (Highest Risk).Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).
Amiodarone use should be avoided with lopinavir/ritonavir, but if the combination must be used, monitor closely for increased amiodarone serum concentrations and effects.RomiDEPsin: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of RomiDEPsin. Drugs; lithium, amiodarone, non-selective beta- drugs: Amiodarone or lithium; anti-thyroid blockers in the pictures on the arteriolar system. Management: Consider alternatives to this drug combination. Your doctor may suggest you take a multivitamin supplement.Orlistat may unbalance an anticonvulsant (antiepileptic) treatment, by decreasing the absorption of antiepileptic medicines, thus leading to convulsions. Patients with additional risk factors for QTc prolongation may be at even higher risk.Clopidogrel: Amiodarone may decrease serum concentrations of the active metabolite(s) of Clopidogrel. As with any weight-control program, over-consumption of fat and calories may reduce any weight loss effect.This medicine can cause harmless changes in your bowel habits, such as fatty or oily stools, due to the elimination of undigested fat in your faeces. Lopinavir may increase the serum concentration of Amiodarone. Voriconazole may increase the serum concentration of Amiodarone. Avoid extravasation.• Neurotoxicity: Peripheral neuropathy has been reported rarely with chronic administration; may resolve when amiodarone is discontinued, but resolution may be slow and incomplete.• Ocular effects: Regular ophthalmic examination (including slit lamp and fundoscopy) is recommended. To help weight loss in conjunction with a lower-fat, mildly hypocaloric diet.
Amiodarone may increase the serum concentration of Fosphenytoin.Fusidic Acid (Systemic): May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Gadobenate Dimeglumine: QT-prolonging Agents (Highest Risk) may enhance the QTc-prolonging effect of Gadobenate Dimeglumine.
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