Impact of a national propofol shortage on duration of mechanical ventilation at an academic medical center. Mayr Aprotinin during coronary-artery bypass grafting and risk of death. Nebenwirkungen.  R, Sweet Minims Phenylephrine Hydrochloride 2.5%w/v Eye Drops, Solution Minims Phenylephrine Hydrochloride 10%w/v Eye Drops, Solution Problem / background Bausch and Lomb are the sole UK supplier of Minims Phenylephrine Hydrochloride eye drops. The shortage of preservative-free, bisulfite-free epinephrine—used in cataract surgery for its ability to maintain mydriasis—began last year and shows no signs of ending any time soon.  SL, Linde-Zwirble Griffith  R, Chi  et al. Error bars indicate 95% confidence intervals.Customize your JAMA Network experience by selecting one or more topics from the list below.Vail E, Gershengorn HB, Hua M, Walkey AJ, Rubenfeld G, Wunsch H. Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. In Europe and other parts of the world, cataract surgeons have the option of using commercially available bisulfite-free phenylephrine and diluting it 1:4 with BSS, BSS Plus, or preservative-free lidocaine (as in the Spanish study cited above). Statistical Analysis Vasopressor Trends “Bisulfite 0.1 percent is commonly used to stabilize commercially available ampules of 1:1,000 epinephrine,” said David F. Chang, MD, in practice in Los Altos, Calif., and at the University of California, San Francisco.  TJ.  M, Brody  SS.  S, Design, setting, and participants: Retrospective cohort study of 26 US hospitals in the … We excluded hospitals with a baseline norepinephrine rate of less than 60% of patients with septic shock to both maximize the number of hospitals included and increase the likelihood that clinicians would experience a shortage of the first-line vasopressor within their hospital.The possible norepinephrine shortage period in each hospital was defined as the 4 quarters of calendar year 2011 (as reported on the FDA’s drug shortage website).Hospitals with norepinephrine use that did not decrease by more than 20% in any quarter of 2011 were designated as consistent-use hospitals and used for comparison with shortage hospitals in a secondary difference-in-differences (DID) analysis.  et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. We conducted a retrospective analysis of administrative and pharmacy billing data captured in the Premier Healthcare Database between July 1, 2008, and June 30, 2013.Patients with septic shock were defined as adults (aged ≥18 years) admitted to US acute care hospitals and meeting criteria for severe sepsis using a previously validated algorithm that uses a combination of The study period was divided into quarter years (3-month periods), and the baseline period was defined as the first 8 quarters of data (July 2008 through June 2010) (eFigure 1 in the We excluded low-volume hospitals (defined as those with <500 septic shock admissions during the study period, or <5 septic shock admissions in any study quarter) to ensure that a small change in the number of patients receiving norepinephrine did not disproportionately affect observed hospital-level rates of norepinephrine use.

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