The dosing recommendations should be followed closely and the dose should be lowered if any evidence of bronchospasm is observed during up-titration.In general, β-blockers may mask some of the manifestations of In a trial designed to examine the effects of carvedilol on glycemic control in a population with mild-to-moderate hypertension and well-controlled β-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with Rarely, use of carvedilol in patients with heart failure has resulted in deterioration of renal function.
It is recommended that COREG CR be started at 20 mg once daily and increased after 3 to 10 days, based on tolerability, to 40 mg once daily, then again to the target dose of 80 mg once daily. In a long‑term, placebo‑controlled trial in severe heart failure (COPERNICUS), hypotension and postural hypotension occurred in 15.1% and syncope in 2.9% of subjects with heart failure receiving carvedilol compared with 8.7% and 2.3% of placebo subjects, respectively. Heart rate fell by about 7.5 beats per minute at 50 mg per day. The only additional adverse events reported in CAPRICORN in greater than 3% of the subjects and more commonly on carvedilol were dyspnea, anemia, and lung edema. An Australia‑New Zealand double‑blind, placebo‑controlled trial enrolled 415 subjects (half randomized to immediate‑release carvedilol) with less severe heart failure. Inactive ingredients consist of colloidal Carvedilol is a white to off-white powder with a molecular weight of 406.5 and a molecular formula of CCOREG is indicated for the treatment of mild-to-severe chronic COREG should be taken with food to slow the rate of absorption and reduce the incidence of orthostatic effects.DOSAGE MUST BE INDIVIDUALIZED AND CLOSELY MONITORED BY A PHYSICIAN DURING UP-TITRATION. If such symptoms occur, diuretics should be increased and the dose of COREG CR should not be advanced until clinical stability resumes Patients with bronchospastic disease (e.g., chronic bronchitis, emphysema) should, in general, not receive β‑blockers. There were no reports of bradycardia in the clinical trial of COREG CR in hypertension. The trial was conducted in Eastern and Western Europe, the United States, Israel, and Canada.
Dispense in a tight, light-resistant container.COREG CR and COREG are trademarks owned by or licensed to the GSK group of companies.The other brand listed is a trademark owned by or licensed to its owner and is not owned by or licensed to the GSK group of companies. The recommended starting dose of COREG CR is 10 mg once daily for 2 weeks. At a dosage of 300 mg per kg per day (greater than or equal to 50 times the MRHD as mg per mAvailable data regarding use of COREG in pregnant women are insufficient to determine whether there are drug-associated risks of adverse developmental outcomes. It is recommended that blood glucose be monitored when dosing with COREG CR is initiated, adjusted, or discontinued. There were no age‑ or gender‑related differences in response. Rates of adverse events were generally similar across demographic subsets (men and women, elderly and non‑elderly, blacks and non‑blacks). In general, as is true for other β-blockers, responses were smaller in black than non-black subjects. Do not give COREG to other people, even if they have the same symptoms you have.
Postural hypotension occurred in 1.8% and syncope in 0.1% of hypertensive subjects receiving immediate‑release carvedilol, primarily following the initial dose or at the time of dose increase, and was a cause for discontinuation of therapy in 1% of subjects.In the CAPRICORN trial of survivors of an acute myocardial infarction with left ventricular dysfunction, hypotension or postural hypotension occurred in 20.2% of subjects receiving carvedilol compared with 12.6% of placebo subjects.
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