The two large trials were carried out simultaneously in North America and in various centers throughout Europe and the rest of the world [the TARGET (Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability Study) trial], with the intention of combining data once the trials were completed A total of 353 patients were enrolled in the North American trial and 668 patients in the TARGET trial.
Further information is needed to determine whether or not aromatase inhibitors should be used in place of tamoxifen. PDF Version – 135KB. These drugs work to block cell receptors like estrogen and progesterone in breast cancers that are hormone receptor positive. Common side effects include: hot flashes, fatigue, changes in mood, depression and night sweats. Listen to your body.
My main complaint with tamoxifen was uncontrollable mood swings and joint pain. My decision to stop taking the medication was right for me.On several breast cancer blogs and forums, I’ve found there are many women who’ve chosen to stop taking their aromatase inhibitors.
I also had lymph node involvement. The drug was shown to have efficacy in hormone receptor-positive breast cancer, but its use was limited by the concomitant suppression of cortisol and aldosterone production. Multiple trials with widely varying study designs have been launched in the adjuvant setting comparing the aromatase inhibitors to tamoxifen. During that time, I’ve added a host of natural supplements to my daily anti-cancer regimen. Several randomized trials demonstrated that the third-generation aromatase inhibitors were equivalent or superior to megestrol acetate in this setting Two large trials demonstrated the clinical equivalency of anastrozole and megestrol acetate in women who had failed first-line tamoxifen Letrozole was also shown to have similar efficacy to megestrol acetate in two large randomized studies. Aromatase inhibitors (AIs), like arimidex, aromasin and femara, are also used to help fight cancer cell regrowth. Patients whose tumors overexpressed HER2/neu (14% of tumors) were significantly less likely to respond to tamoxifen as compared with patients whose tumors did not overexpress HER2/neu (17 These studies suggest that the aromatase inhibitors may be useful in the treatment of early-stage breast cancer. The North American trial raised the possibility that anastrozole may be superior to tamoxifen In contrast, the TARGET trial showed no statistically significant differences between the anastrozole and tamoxifen arms for any of the study endpoints Combined analysis of data from these two trials failed to show a significant difference between the two treatments One other small, nonblinded, randomized trial compared anastrozole to tamoxifen for first-line treatment of metastatic breast cancer. These trials aim to demonstrate which hormonal therapy leads to the lowest rates of breast cancer recurrence and produces the most favorable side effect profile.
According to an But even with all of its benefits, Tamoxifen does come with side effects. Tamoxifen made me feel even more horrible than I felt on the arimidex or the aromasin.
No longer do I suffer from gigantic mood swings, depression, bouts of constant crying, and overall fatigue. Like all drugs, aromatase inhibitors can cause side effects, but it’s not possible to predict how any of the drugs will affect an individual. I would never suggest you stop taking your medication. I weighed several factors such as my family medical history, my oncotype DX and fluorescence in situ hybridization (FISH) scores, my stage and grade of breast cancer along with the number of lymph nodes involved. Studies have shown no impact on cortisol or aldosterone levels in patients being treated with 3–10 mg/day anastrozole for up to 3 months Only one study has compared the clinical efficacy of third-generation aromatase inhibitors.
Side effects of aromatase inhibitors Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer. Some preclinical data suggest that there may be differences in the degree of estrogen suppression and in the selectivity of the drugs for the aromatase enzyme.
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