0000015152 00000 n 0000171753 00000 n 0000013256 00000 n The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. The apparent mean (95% CL) volume of distribution at steady-state was 942 (870, 1014) mL/kg body weight.Oclacitinib is metabolized in the dog to multiple metabolites and one major oxidative metabolite was identified in plasma and urine. The difference between VAS scores on Day 0 (pre-treatment) and Day 14 was used to calculate the least squares mean percentage reduction from baseline for each treatment group, and contrasts were used to compare treatments.CADESI-02=Canine Atopic Dermatitis Extent and Severity Index, Version 2; Pruritus VAS=Visual Analog Scale (0-100 mm)You are leaving the country website to access another site in the group.Regulatory constraints and medical practices vary from country to country. 0000415164 00000 n By Day 30, 86% (127/147) of the placebo group dogs and 15% (23/152) of the APOQUEL group dogs withdrew from the masked study because of worsening clinical signs, and had the option to enroll in an unmasked study and receive APOQUEL. 0000200379 00000 n 0000004174 00000 n Treatment success for skin lesions was defined as a 50% decrease from the baseline Canine Atopic Dermatitis Extent and Severity Index (CADESI) score, assessed by the Veterinarian, on Day 28. All rights reserved. APOQUEL was administered at a dosage of 0.4-0.6 mg/kg twice daily for 14 days, followed by 0.4-0.6 mg/kg once daily up to Day 28 (±2) and was compared to a control group administered prednisolone at a dose rate of 0.5-1.0 mg/kg once daily up to Day 6 (±1), followed by 0.5-1.0 mg/kg every second day up to Day 28 (±2).The primary efficacy variable was the percentage reduction from baseline (pre-treatment) for owner-assessed pruritus at Day 14 of the study. Adverse reactions reported (and percent of dogs affected) during Days 0-16 included diarrhea (4.6% APOQUEL, 3.4% placebo), vomiting (3.9% APOQUEL, 4.1% placebo), anorexia (2.6% APOQUEL, 0% placebo), new cutaneous or subcutaneous lump (2.6% APOQUEL, 2.7% placebo), and lethargy (2.0% APOQUEL, 1.4% placebo). Of these 239 dogs, one dog developed demodicosis following 273 days of APOQUEL administration. 0000025479 00000 n 0000002469 00000 n The most common includeBalancing the need for relief with the consideration of side effects can create an emotional roller coaster for pet ownersSide effects were similar to placebo over short termCan be used concomitantly with many medications, including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-specific immunotherapyNot for use in dogs with serious infections or for use in breeding, pregnant or lactating dogs“APOQUEL is a reliable, fast-acting way to ensure the pet finds relief from itching.”“APOQUEL works well to provide relief, increasing owners' confidence in our recommendation and building trust that we are going to help their pets.”“Whenever you solve a problem for a pet owner, it always results in increased trust and more acceptance of other recommendations.”*Based on survey data from veterinarians (n=250) and pet owners (n=150).Save the APOQUEL dosing table to use in your practiceA comprehensive overview of allergic skin disease and APOQUEL, including pharmacology and clinical trialsA simple diagram that reviews short- and long-term side effects of steroidsDownload and share this video with pet owners in your waiting roomPet owners put can put their own dogs in the APOQUEL TV commercial via this app to share on their social media.Gives dog owners a quick overview of allergic skin disease and a review of APOQUEL treatment, explaining what to expectHelps your clients track the improvement in their dog’s itchAn informative review of APOQUEL for your customers; can be used in the waiting room or given to owners whose dogs have been prescribed APOQUELAll trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.CADESI-02=Canine Atopic Dermatitis Extent and Severity Index, Version 2; Pruritus VAS=Visual Analog Scale (0-100 mm)This study was conducted as a randomized, controlled, multicenter, blinded 28-day clinical trial of 123 dogs.

Eating Too Many Grapes Side Effects Cardizem, Azelaic Acid And Metrogel Together Loxitane, Clostridium In Birds Arimidex, Gabapentin Sales Prandin, Acarbose Weight Loss Genegra, Albendazole For Deworming Dogs Femcare, Hair Growth Reddit Genegra, Raqib And Atid Bystolic, Ritalin And Antibiotics Zestoretic, Best Vitamin D3 And K2 Supplements UK Vigora, How Much Flecainide Can You Take Doxycycline, Duolin Inhaler For Infants Suhagra, Is It Okay To Take Lorazepam With Benadryl Motilium, Methotrexate Chemo Brain, Is Yaz Safe Coreg, Vellulli Karam After Delivery Plavix, Bitter Melon Weight Loss Testimonials Lipitor, Donepezil Nhs Elocon, Aripiprazole Injection Micronase, Vigrx Oil Where To Buy Diclofenac Gel, Acyclovir Cream Walgreens Kamagra Flavored, Rifampicin Obat Apa Paxil, Nuvaring Side Effects Mood Dilantin, Where To Buy Caboki Azulfidine,