They efficiently catalyze the reversible hydration of CO 2 to bicarbonate. They may also be used to treat seizure disorder and acute mountain sickness. The X-ray crystal structure of the hCA II-indapamide adduct was also resolved at high resolution.Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy.This is version 1.3 of the entry.
The compounds were investigated for the inhibition of four mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) of pharmacologic relevance, that is, the human (h) hCA I, II, IX and XII, drug targets for antiglaucoma (hCA II and XII) or antitumor (hCA IX/XII) agents. Carbonic anhydrase inhibitors reduce the activity of carbonic anhydrase, an enzyme responsible for catalyzing the reaction between carbon dioxide and water into carbonic acid and then bicarbonate.
Inhibitors of carbonic anhydrase are used to treat glaucoma, the excessive build up of water in the eyes. Quality Control; Quality Assurance; R&D. Product Categories. Contact Us; Information & Sample Request; Careers; Search. Generally, the electrolyte effects of carbonic anhydrase inhibitors are mild and they are typically not used for their diuretic capacity. Natural products that Research and Development; R&D Highlights; Products – Under Active Development; CRAMS; Contact Us. Micromedex, Inc. Englewood, CO. 1995. antiobesity agent, carbonic anhydrase, enzyme inhibitor, isozyme, sulfamate, sulfamide, sulfonamide, tumor-progression marker Inhibitors of the zinc enzyme carbonic anhydr ase (CA) targeting diff erent isozymes among the 15 presently reported in humans have va … When this happens, the partial pressure of CO2 in the lungs (pCO2) decreases (is "blown off"), causing a Bennett WM, Aronoff GR, Golper TA, et al, Drug Prescribing in Renal Failure, American College of Physicians, Philadelphia, PA, 1987Product Information: Neptazane(R), methazolamide. The compounds were moderate or inefficient hCA I inhibitors (off-target isoform for both applications), efficiently inhibited … We comply with the HONcode standard for trustworthy health information -
CAIs also include more recent drugs/investigational agents such as dorzolamide (compound 6), brinzolamide (compound 7), indisulam
Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. Select one or more newsletters to continue. Introduction: Carbonic anhydrases (CA; EC: 4.2.1.1) are zinc enzymes present in both prokaryotes and eukaryotes. A carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in …
In the kidney, the control of bicarbonate ions influences the water content of the cell. Biological assembly 1 assigned by authors and generated by PISA (software)Diuretics such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide, and bumetanide containing primary sulfamoyl moieties were reevaluated as inhibitors of 12 human carbonic anhydrases (hCAs, EC ...Diuretics such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide, and bumetanide containing primary sulfamoyl moieties were reevaluated as inhibitors of 12 human carbonic anhydrases (hCAs, EC 4.2.1.1).
Micromedex, Inc. Englewood, CO. 1995. Acetazolamide, dichlorphenamide, and methazolamide are carbonic anhydrase inhibitors.Carbonic anhydrase inhibitors also decrease the secretion of aqueous humor (the aqueous humor is the clear fluid that fills the space between the lens and the cornea of the eyeball), which results in a decrease in intraocular pressure.Carbonic anhydrase inhibitors are mainly used for the treatment of Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Medical conditions associated with carbonic anhydrase inhibitors:Gavreto (pralsetinib) is an oral selective RET kinase inhibitor for the...Detectnet (copper Cu 64 dotatate) is a radioactive diagnostic agent indicated...Onureg (azacitidine) is a nucleoside metabolic inhibitor indicated for the...Qdolo (tramadol hydrochloride) is an opioid agonist indicated in adults for ...The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
The new sulfonyl semicarbazides were tested against a panel of hCA isoforms I, II, IX, and XII, using acetazolamide (AZA, 1) as standard.All the sulfonyl semicarbazides showed subnanomolar affinity for hCA XII (pK i range 0.59–0.79 nM) and high … Available for Android and iOS devices. A series of novel sulfonyl semicarbazides 5–13 was designed, synthesized, and evaluated for human carbonic anhydrase (hCA) inhibition.
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