The symptoms? Learn simple...False ideas scare many depression suffers away from therapy and the quick relief and help these pros can provide. Drug warnings and other concerns. If cataracts form, treatment should be discontinued.The following adverse reactions are discussed in more detail in other sections of the labeling:Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.The information below is derived from a clinical trial database for Seroquel consisting of over 4300 patients.In the acute therapy of schizophrenia (up to 6 weeks) and bipolar mania (up to 12 weeks) trials, the most commonly observed adverse reactions associated with the use of Seroquel monotherapy (incidence of 5% or greater) and observed at a rate on Seroquel at least twice that of placebo wereIn the acute adjunct therapy of bipolar mania (up to 3 weeks) studies, the most commonly observed adverse reactions associated with the use of Seroquel (incidence of 5% or greater) and observed at a rate on Seroquel at least twice that of placebo wereTable 10 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during therapy (up to 3 weeks) of acute mania in 2% or more of patients treated with Seroquel (doses ranging from 100 to 800 mg/day) used as adjunct therapy to Table 11 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during therapy (up to 8 weeks) of bipolar Explorations for interactions on the basis of gender, age, and race did not reveal any clinically meaningful differences in the adverse reaction occurrence on the basis of these demographic factors.The following adverse reactions have also been reported with quetiapine:While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. The adverse event leading to discontinuation in 1% or more of patients on Seroquel and at a greater incidence than placebo was somnolence (2.7% and 0% for placebo).The incidence of discontinuation due to adverse reactions for quetiapine-treated and placebo-treated patients was 11.4% and 4.4%, respectively. The cholinesterase inhibitors were broadly associated with increased risk for gastrointestinal adverse events. Other patients had experienced mild adverse effects and resolved spontaneously. Learn about schizophrenia symptoms, signs, and treatment. Common side effects of Seroquel include headache, agitation, dizziness, drowsiness/tiredness, weight gain, and stomach upset. The adverse reactions leading to discontinuation in 2% or more of patients on Seroquel and at a greater incidence than placebo were somnolence (4.1% vs. 1.1%) and In therapy for schizophrenia (up to 6 weeks), the most commonly observed adverse reactions associated with the use of quetiapine in adolescents (incidence of 5% or greater and quetiapine incidence at least twice that for placebo) were somnolence (34%), dizziness (12%), dry mouth (7%), tachycardia (7%).In bipolar mania therapy (up to 3 weeks) the most commonly observed adverse reactions associated with the use of quetiapine in children and adolescents (incidence of 5% or greater and quetiapine incidence at least twice that for placebo) wereIn an acute (8-week) Seroquel XR trial in children and adolescents (10-17 years of age) with bipolar depression, in which efficacy was not established, the most commonly observed adverse reactions associated with the use of Seroquel XR (incidence of 5% or greater and at least twice that for placebo) wereThe following findings were based on a 6-week placebo-controlled trial in which quetiapine was administered in either doses of 400 or 800 mg/day.Table 13 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during therapy (up to 6 weeks) of schizophrenia in 2% or more of patients treated with Seroquel (doses of 400 or 800 mg/day) where the incidence in patients treated with Seroquel was at least twice the incidence in placebo-treated patients.Adverse reactions that were potentially dose-related with higher frequency in the 800 mg group compared to the 400 mg group includedThe following findings were based on a 3-week placebo-controlled trial in which quetiapine was administered in either doses of 400 or 600 mg/day.In bipolar mania therapy (up to 3 weeks) the most commonly observed adverse reactions associated with the use of quetiapine in children and adolescents (incidence of 5% or greater and quetiapine incidence at least twice that for placebo) wereTable 14 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during therapy (up to 3 weeks) of bipolar mania in 2% or more of patients treated with Seroquel (doses of 400 or 600 mg/day) where the incidence in patients treated with Seroquel was greater than the incidence in placebo-treated patients.Adverse reactions that were potentially dose-related with higher frequency in the 600 mg group compared to the 400 mg group includedIn a short-term placebo-controlled monotherapy trial in adolescent patients with schizophrenia (6-week duration), the aggregated incidence of extrapyramidal symptoms was 12.9% (19/147) for Seroquel and 5.3% (4/75) for placebo, though the incidence of the individual adverse reactions (akathisia, tremor, extrapyramidal disorder, hypokinesia, restlessness, psychomotor hyperactivity, muscle rigidity, dyskinesia) did not exceed 4.1% in any treatment group.In a short-term placebo-controlled monotherapy trial in children and adolescent patients with bipolar mania (3-week duration), the aggregated incidence of extrapyramidal symptoms was 3.6% (7/193) or Seroquel and 1.1% (1/90) for placebo.Table 15 presents a listing of patients with adverse reactions potentially associated with extrapyramidal symptoms in the short-term placebo-controlled monotherapy trial in adolescent patients with schizophrenia (6-week duration).Table 16 presents a listing of patients with adverse reactions associated with extrapyramidal symptoms in a short-term placebo-controlled monotherapy trial in children and adolescent patients with bipolar mania (3-week duration).In placebo-controlled monotherapy clinical trials involving 3368 patients on quetiapine fumarate and 1515 on placebo, the incidence of at least one occurrence of neutrophil count <1.0 x 10In the acute (6-week) schizophrenia trial in adolescents, increases in heart rate (>110 bpm) occurred in 5.2% (3/73) of patients receiving Seroquel 400 mg and 8.5% (5/74) of patients receiving Seroquel 800 mg compared to 0% (0/75) of patients receiving placebo.

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