Absolutely agree. Is your hemoglobin/hematocrit normal?

You're very knowledgeable and you surely helped me a lot!The Iron Disorders Institute has a lot of reference material that may be helpful.

#5: A single blood donation should produce significant results if iron related inflammation is what's causing ferritin elevation.

I really don't know about the hepcidin/TSAT relationship, but it would seem to make sense that if iron is in lock-down from high hepcidin, this might push TSAT lower and possibly mask an iron overload (but then I really don't know). Lactoferrin's main functions in the body include binding with and transporting iron. Overview Information Lactoferrin is a protein found in cow milk and human milk. Lactoferrin is a glycoprotein that plays an important role in the human innate immune system.

This is the most important indicator of iron loading when ferritin is elevated, & you really want to see this (saturation) in the middle third of its normal range. This was indicated by a decrease in the levels of two bone resorption markers (One of the important properties of lactoferrin is its ability to bind with nucleic acids.

As long as TSAT is middle third, you should not have a substantial iron overload.

A study published in July 2009 examined the effects of lactoferrin versus an iron supplement (ferrous sulfate) in a group of pregnancy women with anemia.

I wonder if taking lactoferrin won't make things worse?When ferritin is high but serum iron or iron saturation (transferrin saturation / TSAT) is low, this may be due more to inflammation than iron overload.

Whether I should use apto- or bound- lactoferrin depends on clearing the ferritin marker (that is, being sure it is not high because of iron overload).Iron saturation, transferrin saturation and TSAT are all one in the same. But very rarely things go crazy for no reason.The point of my question is that, when ferritin and hepcidin are elevated, it MAY be beneficial to lower hepcidin even at the cost of higher inflammation because this will help release some iron stored in the liver (in theory decreasing liver inflammation and chances of cancer) and reduce the chances of anemia.

I have high ferritin (and normal-almost-low iron). I believe inflammation/infection related ferritin and hepcidin probably should rise in lock-step, but then I really don't know. The other 50 must have been inflammation related. Although laboratory ranges vary, most are close to these values. Apparently there are two kinds, and you want "Apo-lactoferrin" if you wish to lower iron with this. Of course that UIBC and TIBC can help and I am ignoring them for academic purposes.I think iron is causing a lot of problems in my liver..."1 - If ferritin is high but TSAT is OK, then ferritin is an inflammation marker and it is fine to take hololactoferrin".

I just couldn't understand the immune effects of lactoferrin when I tried to dig into the weeds, so I punted and stick with the more well known chelators (Curcumin, Quercetin & IP6)Regarding question #2: again TSAT middle third of normal range is OK, upper (or lower) third not so much.

A significant blood loss causes hepcidin levels to plummet for up to a month, as the body, sensing low blood cell volume overrides all in an effort to rebuild red blood.
Notice the normal range for TSAT from the Iron Disorders Institute is set narrower than many lab ranges @ 25-35.

Sorensen and S. P. L. Sorensen, Compf. Normal and Optimal are apparently very different things though! A medical opinion from a real MD is always wise before you embark on any type of alternative quest for better health.

*Are you aware of any transferrin - hepcidin relationship?I get it that TSAT is the GO-TO after ferriting being high.I also get it how you look at it in terms of "middle third". This can result in an angry inflamed liver and a high rate of apoptosis (liver cell turnover).

I'm not a doctor, so always wise to pester your own doc about anything you are considering, be it bloodletting or supplements. Therefore, TSAT will be lower.

The reason why I am looking into lactoferrin is 1) to make iron more bioavaliable because it is low (this was before I knew ferritin was high), 2) increase immune activity, 3) use its antiviral activity and 4) deplete parasites from iron.

As you note, "it shouldn't hurt"; and if you do have an iron issue, it should help.
I assume both are safe (but then I really don't know).

Don't know if you've got easy access to having labs done, but a bit of experimentation might be in order to see what will lower your ferritin without causing your hemoglobin to suffer. Hope this helps, & hope better health is in your future!

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