The role of CYP1A2 is further supported by the finding that the above mentioned ratios were significantly correlated to the paraxanthine/caffeine ratio, an index used to measure CYP1A2 activity [Dose‐dependent elimination of caffeine in humans has been reported in several studies [In conclusion, the present study indicates that caffeine reduces clozapine clearance most likely by inhibiting CYP1A2.


Previously published reports indicate that clozapine is metabolized mainly by CYP1A2 which is responsible for the Our results are consistent with these previous observations although the decrease in clozapine clearance when clozapine was administered with caffeine was moderate.

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This website uses cookies. 0 people have FoundHealth will send you weekly updates on new content in this area. Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.
The decrease in the ratio AUC(0,12h) for desmethyl‐clozapine and AUC(0,12h) for clozapine indicates that the underlying mechanism is reduced CYP1A2 activity caused by caffeine intake. , Clozapine-Resistant Psychosis, Smoking, and Caffeine: Managing the Neglected Effects of Substances That Our Patients Consume Every Day, Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Effects of Caffeine on the Kinetics of Fluvoxamine and its Major Metabolite in Plasma After a Single Oral Dose of the Drug, An Overview of Psychotropic Drug-Drug Interactions, Effect of Caffeine-Containing versus Decaffeinated Coffee on Serum Clozapine Concentrations in Hospitalised Patients, Influence of Dose, Cigarette Smoking, Age, Sex, and Metabolic Activity on Plasma Clozapine Concentrations, Drug Interactions Between Herbal and Prescription Medicines, Therapeutic Drug Monitoring Data on Olanzapine and Its N-Demethyl Metabolite in the Naturalistic Clinical Setting, Central nervous system stimulants, drugs that suppress appetite, and drugs used in Alzheimer's disease, Potential effects of herbal medicinals on perioperative care, Seminars in Anesthesia, Perioperative Medicine and Pain, 2 people have experienced St. John's Wort.

Written by © 2020 Share the details of your treatment experience. Caffeine is an inhibitor of CYP1A2 and patients taking clozapine should be encouraged to keep their caffeine intake stable and to report substantial changes to their prescriber. Caffeine, oral decongestants (such as pseudoephedrine and phenylephrine), stimulants (such as armodafinil, amphetamine, methylphenidate, and modafinil), theophylline, selegiline Parkinson disease Certain antinausea drugs ( metoclopramide , prochlorperazine , promethazine ) and most antipsychotics except a few such as quetiapine and clozapine

One study raised questions about possible antifertility effects of St. John's wort.

However, it is clear that this compound has many of the features … The information provided here is for informational purposes only. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username No one has made any comments yet. In the extensive German experience with St. John's wort as a treatment for depression, there have been no published reports of serious adverse consequences from taking the herb alone. In the e… Message: In a study designed to look for side effects, 3,250 people took St. John's wort for 4 weeks. The unintended result may be to reduce the potency of standard anti-HIV drugs.

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