... DUONASE Nasal Spray. Onset of action was observed as early as 30 minutes following the initial dose of azelastine hydrochloride and fluticasone propionate nasal spray.The subjective impact of seasonal allergic rhinitis on a patient's health-related quality of life was evaluated by the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) (28 items in 7 domains (activities, sleep, non-nose/eye symptoms, practical problems, nasal symptoms, eye symptoms, and emotional) evaluated on a 7-point scale where 0=no impairment and 6=maximum impairment), which was administered to patients 18 years of age and older. Stimate Nasal Spray contains 1.5 mg/mL desmopressin acetate in an aqueous solution at a pH of approximately 5. Azelastine Hydrochloride and Fluticasone Propionate Nasal SprayTable 2 contains adverse reactions reported with frequencies greater than or equal to 2% and more frequently than placebo in patients treated with azelastine hydrochloride and fluticasone propionate nasal spray in the seasonal allergic rhinitis controlled clinical trial.Table 2.

Overall, 1% of patients in both the azelastine hydrochloride and fluticasone propionate nasal spray and placebo groups discontinued due to adverse reactions.Table 1 contains adverse reactions reported with frequencies greater than or equal to 2% and more frequently than placebo in patients treated with azelastine hydrochloride and fluticasone propionate nasal spray in the seasonal allergic rhinitis controlled clinical trials.In the above trials, somnolence was reported in <1% of patients treated with azelastine hydrochloride and fluticasone propionate nasal spray (6 of 853) or vehicle placebo (1 of 861) [The safety data described below in children 6-11 years of age reflect exposure to azelastine hydrochloride and fluticasone propionate nasal spray in 152 patients (6 to 11 years of age; 57% male and 43% female) with seasonal allergic rhinitis in one double-blind, placebo-controlled clinical trial of 2-week duration. Because the drug works on the central If this new drug makes it through all the safety and effectiveness trials required for FDA approval, it could not only be a valuable treatment but also could put Spana's tiny company on the map. Caution patients against engaging in hazardous occupations requiring complete mental alertness and motor coordination such as driving or operating machinery after administration of azelastine hydrochloride and fluticasone propionate nasal spray [Advise patients to avoid concurrent use of azelastine hydrochloride and fluticasone propionate nasal spray with alcohol or other central nervous system depressants because additional reductions in alertness and additional impairment of central nervous system performance may occur [Nasal corticosteroids are associated with epistaxis, nasal ulceration, nasal septal perforation, Inform patients that glaucoma and cataracts are associated with nasal and inhaled corticosteroid use. Participants were considered to be smokers if they had, after stopping smoking, taken a single puff of a cigarette, used other forms of tobacco, used a nicotine drug other than that prescribed, had a carbon monoxide concentration of  10 ppm, or were lost to follow up. Adverse Reactions with ≥2% Incidence and More Frequently than Placebo in Placebo-Controlled Trials of 2 Weeks Duration with Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray in Children 6 to 11 Years of Age with Seasonal Allergic RhinitisAzelastine Hydrochloride and Fluticasone Propionate Nasal Spray(N=152)**Safety Population N=152, intent-to-treat population N=152Long-Term (12-Month) Safety Trial in Adults and Adolescents 12 Years of Age and OlderGeneral disorders and administration site condition:Azelastine hydrochloride and fluticasone propionate nasal sprayAzelastine hydrochloride and fluticasone propionate nasal spray:Azelastine hydrochloride and fluticasone propionateDifference From Azelastine Hydrochloride and Fluticasone Propionate Nasal SprayTable 5: Mean Change from Baseline in Reflective Total Nasal Symptom Scores over 2 weeks in Children age 6 to 11 yearsConcurrent Use of Alcohol and other Central Nervous System DepressantsAzelastine Hydrochloride and Fluticasone Propionate Nasal SprayWhat is azelastine hydrochloride and fluticasone propionate nasal spray?What should I tell my healthcare provider before using azelastine hydrochloride and fluticasone propionate nasal sprayazelastine hydrochloride and fluticasone propionate nasal sprayTell your healthcare provider about all the medicines you takeEspecially tell your healthcare provider if you take:azelastine hydrochloride and fluticasone propionate nasal sprayazelastine hydrochloride and fluticasone propionate nasal sprayazelastine hydrochloride and fluticasone propionate nasal sprayzelastine hydrochloride and fluticasone propionate nasal sprayCall your healthcare provider or get medical help right away if you have symptoms of any of the serious side effects listed above.azelastine hydrochloride and fluticasone propionate nasal sprayazelastine hydrochloride and fluticasone propionate nasal sprayGeneral information about the safe and effective use of azelastine hydrochloride and fluticasone propionate nasal sprayazelastine hydrochloride and fluticasone propionate nasal sprayAzelastine Hydrochloride and Fluticasone Propionate Nasal SprayFor use in your nose only.

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