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Tamoxifen is typically taken daily by mouth for five years for breast cancer. Fulvestrant is administered in the form of two injections, each of them injected into a different buttock. xref 0000274711 00000 n 0000314150 00000 n 0000166374 00000 n 0000295230 00000 n 0000258482 00000 n 0000240398 00000 n 0000226844 00000 n 0000165313 00000 n 0000210436 00000 n Downregulation of ER is hypothesized as a cause of acquired resistance to tamoxifen, although it is not downregulated in approximately a quarter of tumors with acquired resistance to tamoxifen and a fifth of the tamoxifen resistant cancers will go on to be responsive to treatment with an AI or a SERM (e.g., Fulvestrant) (81, 82). 0000305734 00000 n 0000337411 00000 n 0000248899 00000 n

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