Some cases may be severe and prolonged. It is important to have a regular carbohydrate intake due to the increased risk of hypoglycaemia if a meal is taken late, if an inadequate amount of food is consumed or if the food is low in carbohydrate. This phenomenon is known as secondary failure which is distinct from primary failure, when an active substance is ineffective as first-line treatment. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Hypoglycaemia is more likely to occur during low-calorie diets, following prolonged or strenuous exercise, alcohol intake or if a combination of hypoglycaemic agents is being used.Hypoglycaemia may occur following administration of sulfonylureas (see section 4.8). Type 1 diabetes is treated with:

• Severe renal or hepatic insufficiency: in these cases the use of insulin is recommended, insulin, 13 L. These doses may not provide additional benefit. Take gliclazide exactly as your doctor has told you. • Blood and lymphatic system disorders: Changes in haematology are rare.They may include anaemia, leucopenia, thrombocytopenia, granulocytopenia.These are in general reversible upon discontinuation of medication. Visit the Selected from data included with permission and copyrighted by First Databank, Inc.

• Combination treatment with other antidiabetic agents:Gliclazide 80 mg can be given in combination with biguanides, alpha glucosidase inhibitors or insulin.In patients not adequately controlled with Gliclazide 80 mg, concomitant insulin therapy can be initiated under close medical supervision.Gliclazide 80 mg should be prescribed using the same dosing regimen recommended for patients under 65 years of age.In patients with mild to moderate renal insufficiency, the same dosing regimen can be used as in patients with normal renal function with careful patient monitoring. • imbalance between physical exercise and carbohydrate intake,
Long term carcinogenicity studies have not been done. Take your dose once a day before breakfast. and a diabetic diet. Sexual stimulation is required for a response to treatment. • concomitant administration of alcohol or certain other medicines (see section 4.5).The pharmacokinetics and/or pharmacodynamics of gliclazide may be altered in patients with hepatic insufficiency or severe renal failure. It may be necessary to adjust the dose of the antidiabetic active substance during and after treatment with glucocorticoids.Increased blood glucose levels due to beta-2 agonist effects.Emphasise the importance of monitoring blood glucose levels.

By continuing to browse the site you are agreeing to our policy on the use of cookies. These data have been confirmed in clinical trials. It is usually recommended that you take it once a day with breakfast. • malnutrition, irregular mealtimes, skipping meals, periods of fasting or dietary changes,

Do not take a double dose to make up for a forgotten dose.

Extended Release: Initial dose: 2.5 to 5 mg orally once a day before first main meal of the day. • a partial inhibition of platelet aggregation and adhesion, with a decrease in the markers of platelet activation (beta thromboglobulin, thromboxane B For slow-release gliclazide, the maximum daily dose is 120mg. Adequate dose adjustment and dietary compliance should be considered before classifying the patient as secondary failure.Disturbances in blood glucose, including hypoglycaemia and hyperglycaemia have been reported, in diabetic patients receiving concomitant treatment with fluoroquinolones, especially in elderly patients.

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